Gut microbiota in cancer immune response and immunotherapy

CB Zhou, YL Zhou, JY Fang - Trends in cancer, 2021 - cell.com
The gastrointestinal tract (GIT) is the largest immune organ and maintains systemic immune
homeostasis in the presence of bacterial challenge. Immune elimination and immune …

Gut microbiome in modulating immune checkpoint inhibitors

X Li, S Zhang, G Guo, J Han, J Yu - EBioMedicine, 2022 - thelancet.com
Gut microbiome has been increasingly recognized for its influence on a diverse array of
human diseases including cancer, and may also influence the outcome of cancer therapies …

Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies

Y Lu, X Yuan, M Wang, Z He, H Li, J Wang… - Journal of hematology & …, 2022 - Springer
The gut microbiota have long been recognized to play a key role in human health and
disease. Currently, several lines of evidence from preclinical to clinical research have …

Cancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes

NLN Ting, HCH Lau, J Yu - Gut, 2022 - gut.bmj.com
Despite the promising advances in novel cancer therapy such as immune checkpoint
inhibitors (ICIs), limitations including therapeutic resistance and toxicity remain. In recent …

Gut microbiome as a potential factor for modulating resistance to cancer immunotherapy

L Shui, X Yang, J Li, C Yi, Q Sun, H Zhu - Frontiers in Immunology, 2020 - frontiersin.org
Gut microbiota refers to the diverse community of more than 100 trillion microorganisms
residing in our intestines. It is now known that any shift in the composition of gut microbiota …

The gut microbiome and efficacy of cancer immunotherapy

G Roviello, LF Iannone, M Bersanelli, E Mini… - Pharmacology & …, 2022 - Elsevier
Cancer treatment has been deeply changed by immunotherapy, achieving unprecedented
improvement in overall and progression-free survival in several advanced and metastatic …

The effect of the gut microbiota on systemic and anti-tumor immunity and response to systemic therapy against cancer

A Aghamajidi, S Maleki Vareki - Cancers, 2022 - mdpi.com
Simple Summary The gut microbiome affects the development of systemic immune response
and it can also impact response to systemic treatments such as immunotherapy and …

Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors

S Rezasoltani, A Yadegar… - Cancer …, 2021 - Wiley Online Library
The human gastrointestinal (GI) tract harbors gut microbiome, which plays a crucial role in
preserving homeostasis at the intestinal host‐microbial interface. Conversely, specific gut …

Effects of microbiota on anticancer drugs: Current knowledge and potential applications

J Huang, W Liu, W Kang, Y He, R Yang, X Mou… - …, 2022 - thelancet.com
Over the last decade, mounting evidence has revealed the key roles of gut microbiota in
modulating the efficacy and toxicity of anticancer drugs, via mechanisms such as …

Cancer and the microbiome—influence of the commensal microbiota on cancer, immune responses, and immunotherapy

V Matson, CS Chervin, TF Gajewski - Gastroenterology, 2021 - Elsevier
The commensal microbiota has been implicated in the regulation of a diverse array of
physiological processes, both within the gastrointestinal tract and at distant tissue sites …