Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation
Amyloid-β (Aβ) peptides are thought to be involved in neurodegenerative diseases such as
Alzheimer's disease and Down's syndrome. They form a large number of polymorphic …
Alzheimer's disease and Down's syndrome. They form a large number of polymorphic …
Location and Conformation of Amyloid β (25–35) Peptide and its Sequence‐Shuffled Peptides within Membranes: Implications for Aggregation and Toxicity in PC12 …
Extracellular deposits of amyloid β (Aβ) aggregates in the brain is the hallmark of
Alzheimer's disease. We present the configurations (location and conformation) and the …
Alzheimer's disease. We present the configurations (location and conformation) and the …
Alzheimer Aβ peptide interactions with lipid membranes: fibrils, oligomers and polymorphic amyloid channels
F Tofoleanu, NV Buchete - Prion, 2012 - Taylor & Francis
Fibrillar aggregates of misfolded amyloid proteins are involved in a variety of diseases such
as Alzheimer disease (AD), type 2 diabetes, Parkinson, Huntington and prion-related …
as Alzheimer disease (AD), type 2 diabetes, Parkinson, Huntington and prion-related …
Aggregation of Alzheimer's amyloid β-peptide in biological membranes: A molecular dynamics study
Numerous studies have concluded that the interaction of the amyloid β-peptide (Aβ) and
cellular membranes contributes to the toxicity and cell death observed in the progression of …
cellular membranes contributes to the toxicity and cell death observed in the progression of …
Effect of surfaces on amyloid fibril formation
Using atomic force microscopy (AFM) we investigated the interaction of amyloid beta (Aβ)(1–
42) peptide with chemically modified surfaces in order to better understand the mechanism …
42) peptide with chemically modified surfaces in order to better understand the mechanism …
A comparative molecular dynamics analysis of the amyloid β-peptide in a lipid bilayer
Because the amyloid β-peptide (Aβ) functions as approximately half of the transmembrane
domain of the amyloid precursor protein and interaction of Aβ with membranes is proposed …
domain of the amyloid precursor protein and interaction of Aβ with membranes is proposed …
Structure, orientation, and surface interaction of Alzheimer amyloid-β peptides on the graphite
The misfolding and aggregation of amyloid-β (Aβ) peptides into amyloid fibrils in solution
and on the cell membrane has been linked to the pathogenesis of Alzheimer's disease …
and on the cell membrane has been linked to the pathogenesis of Alzheimer's disease …
Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease
The association of the amyloid-β (Aβ) peptide with cellular membranes is hypothesized to be
the underlying phenomenon of neurotoxicity in Alzheimer's disease. Misfolding of proteins …
the underlying phenomenon of neurotoxicity in Alzheimer's disease. Misfolding of proteins …
Membrane binding and pore formation by a cytotoxic fragment of amyloid β peptide
Amyloid β (Aβ) peptide contributes to Alzheimer's disease by a yet unidentified mechanism.
In the brain tissue, Aβ occurs in various forms, including an undecapeptide Aβ25-35, which …
In the brain tissue, Aβ occurs in various forms, including an undecapeptide Aβ25-35, which …
Human and rodent Alzheimer β‐amyloid peptides acquire distinct conformations in membrane‐mimicking solvents
L Otvos Jr, GI SZENDREI, VMY LEE… - European Journal of …, 1993 - Wiley Online Library
The major constituent of senile plaques (one of the hallmark lesions of Alzheimer's disease)
is a 42 (43)‐amino‐acid polypeptide, termed the A4 or β‐amyloid peptide. The β‐amyloid …
is a 42 (43)‐amino‐acid polypeptide, termed the A4 or β‐amyloid peptide. The β‐amyloid …