We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1)
extends lifespan and increases resistance to several age-related pathologies in female …

Recent evidence suggests that alterations in insulin/insulin–like growth factor 1 (IGF1)
signaling (IIS) can increase mammalian life span. For example, in several mouse mutants …

Impaired insulin/IGF 1 signalling has been shown to extend lifespan in model organisms
ranging from yeast to mammals. Here we sought to determine the effect of targeted …

Interference in insulin and/or insulin-like growth factor 1 (IGF-1) signaling can extend
invertebrate life span, and interference in IGF-1 signaling can extend murine life span …

Growth hormone deficiency or resistance resulting from spontaneous or experimentally
produced mutations in laboratory mice delay aging and increase lifespan. Alterations in …

Taguchi et al.(Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null
mutation in insulin receptor substrate–2 (Irs2) display a 17% increase in median life span …

During the past year, some novel genetic modifications were shown to alter the lifespan of
mice, thus expanding the list of genes and physiological processes that influence …

Insulin/insulin-like growth factor-I (IGF-I) pathways are recognized as critical signaling
pathways involved in the control of lifespans in lower organisms to mammals. Caloric …

Reduced activity of insulin/insulin-like growth factor signaling (IIS) extends health and life
span in mammals. Loss of the insulin receptor substrate 1 (Irs1) gene increases survival in …

Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in
species throughout the animal kingdom. This life-extension pathway, the first to be defined …