Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1
C Selman, L Partridge, DJ Withers - PloS one, 2011 - journals.plos.org
We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1)
extends lifespan and increases resistance to several age-related pathologies in female …
extends lifespan and increases resistance to several age-related pathologies in female …
Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice
C Selman, S Lingard, AI Choudhury… - The FASEB …, 2008 - Wiley Online Library
Recent evidence suggests that alterations in insulin/insulin–like growth factor 1 (IGF1)
signaling (IIS) can increase mammalian life span. For example, in several mouse mutants …
signaling (IIS) can increase mammalian life span. For example, in several mouse mutants …
Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan
TL Merry, D Kuhlow, B Laube, D Pöhlmann… - Aging …, 2017 - Wiley Online Library
Impaired insulin/IGF 1 signalling has been shown to extend lifespan in model organisms
ranging from yeast to mammals. Here we sought to determine the effect of targeted …
ranging from yeast to mammals. Here we sought to determine the effect of targeted …
Probing the relationship between insulin sensitivity and longevity using genetically modified mice
Interference in insulin and/or insulin-like growth factor 1 (IGF-1) signaling can extend
invertebrate life span, and interference in IGF-1 signaling can extend murine life span …
invertebrate life span, and interference in IGF-1 signaling can extend murine life span …
Impact of reduced insulin‐like growth factor‐1/insulin signaling on aging in mammals: novel findings
A Bartke - Aging cell, 2008 - Wiley Online Library
Growth hormone deficiency or resistance resulting from spontaneous or experimentally
produced mutations in laboratory mice delay aging and increase lifespan. Alterations in …
produced mutations in laboratory mice delay aging and increase lifespan. Alterations in …
Comment on" Brain IRS2 signaling coordinates life span and nutrient homeostasis"
Taguchi et al.(Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null
mutation in insulin receptor substrate–2 (Irs2) display a 17% increase in median life span …
mutation in insulin receptor substrate–2 (Irs2) display a 17% increase in median life span …
New findings in gene knockout, mutant and transgenic mice
A Bartke - Experimental Gerontology, 2008 - Elsevier
During the past year, some novel genetic modifications were shown to alter the lifespan of
mice, thus expanding the list of genes and physiological processes that influence …
mice, thus expanding the list of genes and physiological processes that influence …
Role of insulin and growth hormone/insulin-like growth factor-I signaling in lifespan extension: rodent longevity models for studying aging and calorie restriction
T Chiba, H Yamaza, I Shimokawa - Current Genomics, 2007 - ingentaconnect.com
Insulin/insulin-like growth factor-I (IGF-I) pathways are recognized as critical signaling
pathways involved in the control of lifespans in lower organisms to mammals. Caloric …
pathways involved in the control of lifespans in lower organisms to mammals. Caloric …
Reduced insulin signaling in neurons induces sex-specific health benefits
M Baghdadi, T Nespital, A Mesaros, S Buschbaum… - Science …, 2023 - science.org
Reduced activity of insulin/insulin-like growth factor signaling (IIS) extends health and life
span in mammals. Loss of the insulin receptor substrate 1 (Irs1) gene increases survival in …
span in mammals. Loss of the insulin receptor substrate 1 (Irs1) gene increases survival in …
The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
C Kenyon - … Transactions of the Royal Society B …, 2011 - royalsocietypublishing.org
Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in
species throughout the animal kingdom. This life-extension pathway, the first to be defined …
species throughout the animal kingdom. This life-extension pathway, the first to be defined …