The traditional practice of using high inflation pressures to maintain normal tidal volumes
and arterial blood gases has been encouraged by the perception of uniformly distributed …

Gentle lung ventilation must be standard practice. Because stress and strain are the triggers
of ventilator-induced lung injury, their clinical equivalents should be measured …

Traditional ventilator management of acute respiratory distress syndrome (ARDS),
emphasizing normalization of blood gases, promoted high rates of conventional barotrauma …

The passage of 30 years since the initial description of the acute respiratory distress
syndrome (ARDS) has brought substantial insight into its epidemiology and …

Interest in modified techniques for ventilating patients with acute lung injury (ALI) has been
driven by an evolving knowledge of the respiratory mechanics of this condition and the …

Several alternatives to conventional ventilation in acute lung injury are now available and
have been investigated to a varying degree. The assessment of all such techniques is …

ABSTRACT A large body of animal literature has shown that lungs stretched beyond their
normal maximum are likely to be injured and release inflammatory cytokines into the …

Many experimental studies (1) have suggested that a patient with acute lung injury or adult
respiratory distress syndrome (ARDS) is likely at risk of ventilator-induced lung injury. This …

Airspace collapse is a hallmark of parenchymal lung injury. Strategies to reopen and
maintain patency of these regions offer three advantages: improved gas exchange, less lung …

Acute respiratory distress syndrome (ARDS) is associated with a heterogeneous pattern of
injury throughout the lung parenchyma that alters regional alveolar opening and collapse …