This study compared the effect of monotherapy of colistin, tigecycline, and their combination
in sepsis model of mice. OXA-48 producing Carbapenem-resistant Klebsiella pneumoniae …

Although in vitro data suggest that tigecycline is active against Klebsiella pneumoniae
carbapenemase-producing K. pneumoniae (KPC-Kp), experimental and clinical data are …

Background: Recent scientific reports on the use of high dose tigecycline monotherapy as a
“drug of last resort” warrant further research into the use of this regimen for the treatment of …

Objectives This study investigated the effect of tigecycline exposure on susceptibility of
colistin-resistant Klebsiella pneumoniae isolates to colistin and explored the possibility of …

(KPC-KP). 1 An in vitro study with time-kill assay has shown that TIG, POL and meropenem
(MPN) as single agents do not exhibit efficient bactericidal activity against most of the KPC …

Due to increasing drug resistance, available antimicrobial options are limited in the
treatment of Acinetobacter baumannii infections. Particularly in cases caused by extensively …

Abstract Objectives Carbapenem-resistant Klebsiella pneumoniae (CR-KP) infections
represent severe threats to public health worldwide. The aim of this study was to assess …

This study evaluated the efficacy of tigecycline (TIG), polymyxin B (PMB), and meropenem
(MER) in 80 rats challenged with Klebsiella pneumoniae carbapenemase (KPC)-producing …

Despite the relevance of carbapenemase-producing Klebsiella pneumoniae (CP-Kp)
infections there are a scarce number of studies to evaluate in vivo the efficacy of …

Abstract A matched 1: 2 case–control study was conducted among critically ill patients in
order to identify the risk factors of colistin or tigecycline-resistant carbapenemase-producing …