Ferroptosis is a novel type of nonapoptotic programmed cell death involving the
accumulation of lipid peroxidation (LPO) to a lethal threshold. Herein, we propose tunable …

Ferroptosis, a newfound non-apoptotic cell death pathway that is iron-and reactive oxygen
species (ROS)-dependent, has shown a promise for tumor treatment. However, engineering …

Ferroptosis, an emerging type of cell death found in the past decades, features specifically
lipid peroxidation during the cell death process commonly by iron accumulation …

Intracellular redox homeostasis plays an important role in promoting tumor progression,
development and even treatment resistance. To this end, redox balance impairment may …

Although ferroptosis therapy has been proven to be a promising strategy for cancer
treatment, its efficacy still might be limited by insufficient H2O2 supply in tumor tissue …

Ferroptosis is a currently recognized non-apoptotic cell death mode based on reactive
oxygen species (ROS)-induced lipid peroxidation, which provides a promising strategy for …

Ferroptosis, as an effective sensitizer for apoptosis-based cancer treatments, has been
elucidated to rely on high levels of intracellular oxidative stress mediated by the …

Depleting intracellular glutathione (GSH) has emerged as a potent strategy to combat
cancer. However, the existing GSH-depleting agents are too toxic or ineffective and …

Background Emerging ferroptosis-driven therapies based on nanotechnology function either
by increasing intracellular iron level or suppressing glutathione peroxidase 4 (GPX4) …

Emerging cancer cell ferroptosis features the direct depletion of glutathione (GSH) and
resultant chemical inhibition on glutathione peroxidase 4 (GPX4) bioactivity, which …