Epidermal growth factor receptor mutations in small cell lung cancer

A Tatematsu, J Shimizu, Y Murakami, Y Horio… - Clinical Cancer …, 2008 - AACR
Purpose: The vast majority of epidermal growth factor receptor (EGFR) mutations occur in
lung adenocarcinoma, and even rare cases of other subtypes with this mutation, such as …

[HTML][HTML] Epidermal growth factor receptor mutations in small cell lung cancer: a brief report

TH Shiao, YL Chang, CJ Yu, YC Chang, YC Hsu… - Journal of Thoracic …, 2011 - Elsevier
Introduction: Knowledge about the current status of the epidermal growth factor receptor
(EGFR) has resulted in an improvement in the treatment of non-small cell lung cancer. In …

Small-cell carcinoma with an epidermal growth factor receptor mutation in a never-smoker with gefitinib-responsive adenocarcinoma of the lung

N Alam, KS Gustafson, M Ladanyi, MF Zakowski… - Clinical lung cancer, 2010 - Elsevier
Activating mutations in the epidermal growth factor receptor (EGFR) gene are extremely rare
in small-cell lung cancer (SCLC). Here, we present a case of an EGFR-mutant gefitinib …

Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation

R Morinaga, I Okamoto, K Furuta, Y Kawano… - Lung cancer, 2007 - Elsevier
We report a case of small cell lung cancer (SCLC) developing after prolonged treatment
(more than 2 years) for primary adenocarcinoma of the lung, and we show that both the …

Epidermal growth factor receptor mutation status and clinicopathological features of combined small cell carcinoma with adenocarcinoma of the lung

T Fukui, K Tsuta, K Furuta, S Watanabe… - Cancer …, 2007 - Wiley Online Library
In lung cancer, somatic mutations of epidermal growth factor receptor (EGFR) are
concentrated in exons 18–21, especially in adenocarcinoma (Ad), but these mutations have …

Clinicopathologic Significance of the Mutations of the Epidermal Growth Factor Receptor Gene in Patients with Non–Small Cell Lung Cancer

Y Tomizawa, H Iijima, N Sunaga, K Sato, A Takise… - Clinical cancer …, 2005 - AACR
Purpose: It has been reported that the mutations of epidermal growth factor receptor (EGFR)
are detected in lung cancers. Studies of EGFR mutations in large numbers of patients' …

Heterogeneous Distribution of EGFR Mutations Is Extremely Rare in Lung Adenocarcinoma

Y Yatabe, K Matsuo, T Mitsudomi - Journal of Clinical Oncology, 2011 - ascopubs.org
Purpose Some studies have shown that epidermal growth factor receptor (EGFR) mutations
can be heterogeneously distributed in individual tumors. In this study, we re-evaluated the …

Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma

M Sonobe, T Manabe, H Wada, F Tanaka - British journal of cancer, 2005 - nature.com
Epidermal growth factor receptor (EGFR) mutations are a potential predictor of the
effectiveness of EGFR inhibitors for the treatment of lung cancer. Although EGFR mutations …

Mutations of the Epidermal Growth Factor Receptor Gene in Lung Cancer: Biological and Clinical Implications

T Kosaka, Y Yatabe, H Endoh, H Kuwano, T Takahashi… - Cancer research, 2004 - AACR
Recently it has been reported that mutations in the tyrosine kinase domain of the epidermal
growth factor receptor (EGFR) gene occur in a subset of patients with lung cancer showing a …

Significance of epidermal growth factor receptor gene mutations in squamous cell lung carcinoma

Y Miyamae, K Shimizu, J Hirato, T Araki… - Oncology …, 2011 - spandidos-publications.com
Epidermal growth factor receptor (EGFR) gene mutations have been reported to be clinically
significant in non-small cell lung cancer (NSCLC). However, because most previous studies …