Epidermal growth factor receptor mutations in small cell lung cancer

A Tatematsu, J Shimizu, Y Murakami, Y Horio… - Clinical Cancer …, 2008 - AACR
Purpose: The vast majority of epidermal growth factor receptor (EGFR) mutations occur in
lung adenocarcinoma, and even rare cases of other subtypes with this mutation, such as …

[HTML][HTML] Epidermal growth factor receptor mutations in small cell lung cancer: a brief report

TH Shiao, YL Chang, CJ Yu, YC Chang, YC Hsu… - Journal of Thoracic …, 2011 - Elsevier
Introduction: Knowledge about the current status of the epidermal growth factor receptor
(EGFR) has resulted in an improvement in the treatment of non-small cell lung cancer. In …

Small-cell carcinoma with an epidermal growth factor receptor mutation in a never-smoker with gefitinib-responsive adenocarcinoma of the lung

N Alam, KS Gustafson, M Ladanyi, MF Zakowski… - Clinical lung cancer, 2010 - Elsevier
Activating mutations in the epidermal growth factor receptor (EGFR) gene are extremely rare
in small-cell lung cancer (SCLC). Here, we present a case of an EGFR-mutant gefitinib …

Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation

R Morinaga, I Okamoto, K Furuta, Y Kawano… - Lung cancer, 2007 - Elsevier
We report a case of small cell lung cancer (SCLC) developing after prolonged treatment
(more than 2 years) for primary adenocarcinoma of the lung, and we show that both the …

Epidermal growth factor receptor mutation status and clinicopathological features of combined small cell carcinoma with adenocarcinoma of the lung

T Fukui, K Tsuta, K Furuta, S Watanabe… - Cancer …, 2007 - Wiley Online Library
In lung cancer, somatic mutations of epidermal growth factor receptor (EGFR) are
concentrated in exons 18–21, especially in adenocarcinoma (Ad), but these mutations have …

Clinicopathologic Significance of the Mutations of the Epidermal Growth Factor Receptor Gene in Patients with Non–Small Cell Lung Cancer

Y Tomizawa, H Iijima, N Sunaga, K Sato, A Takise… - Clinical cancer …, 2005 - AACR
Purpose: It has been reported that the mutations of epidermal growth factor receptor (EGFR)
are detected in lung cancers. Studies of EGFR mutations in large numbers of patients' …

Heterogeneous Distribution of EGFR Mutations Is Extremely Rare in Lung Adenocarcinoma

Y Yatabe, K Matsuo, T Mitsudomi - Journal of Clinical Oncology, 2011 - ascopubs.org
Purpose Some studies have shown that epidermal growth factor receptor (EGFR) mutations
can be heterogeneously distributed in individual tumors. In this study, we re-evaluated the …

Mutations of the Epidermal Growth Factor Receptor Gene in Lung Cancer: Biological and Clinical Implications

T Kosaka, Y Yatabe, H Endoh, H Kuwano, T Takahashi… - Cancer research, 2004 - AACR
Recently it has been reported that mutations in the tyrosine kinase domain of the epidermal
growth factor receptor (EGFR) gene occur in a subset of patients with lung cancer showing a …

Significance of epidermal growth factor receptor gene mutations in squamous cell lung carcinoma

Y Miyamae, K Shimizu, J Hirato, T Araki… - Oncology …, 2011 - spandidos-publications.com
Epidermal growth factor receptor (EGFR) gene mutations have been reported to be clinically
significant in non-small cell lung cancer (NSCLC). However, because most previous studies …

Epidermal growth factor receptor mutations in lung cancers

Y Yatabe, T Mitsudomi - Pathology international, 2007 - Wiley Online Library
In 2004, two groups reported somatic mutations in the gene for the epidermal growth factor
receptor (EGFR) in patients with non‐small cell lung cancer (NSCLC), which were highly …