AIM: To assess the regulatory effect of microRNA-185 (miR-185) on lipid metabolism and the
insulin signalling pathway in human HepG2 hepatocytes and a high-fat diet mouse model …

In a microarray study, we found that hepatic miR-291b-3p was significantly increased in
leptin-receptor-deficient type 2 mice (db/db), a mouse model of diabetes. The function of miR …

The expression level of microRNA-802 (miR-802) is increased in livers of high-fat diet (HFD)-
fed mice and obese human subjects; however, the function of miR-802 in the development …

MicroRNAs (miRNAs) are endogenous, noncoding, short, single-stranded RNAs that are
evolutionarily conserved and believed to play a role in controlling a variety of biological …

MicroRNAs are potential therapeutic targets for metabolic diseases. Here, miR-1224-5p was
highly expressed in the livers of mice fed a high-fat diet (HFD) and in obese (ob/ob) mice. To …

Background: Hepatic expression of microRNA-107 is ubiquitously upregulated in various
metabolic diseases. In our previous study, we had demonstrated that fatty acid synthase …

Nonalcoholic fatty liver disease (NAFLD) is characterized by ectopic lipid accumulation and
insulin resistance, yet the underlying molecular mechanisms are poorly understood. MiR …

The incidence of nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia, with their
associated risks of endstage liver and cardiovascular diseases, is increasing rapidly due to …

Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation and is
presently the most common chronic liver disease. However, the mechanisms underlying the …

Background The liver plays a key role in regulating whole body cholesterol homeostasis.
Hepatic cholesterol accumulation causes liver injury in fatty liver disease and …