The PREMIER study: a multicenter, randomized, double‐blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or …
FC Breedveld, MH Weisman… - … : Official Journal of …, 2006 - Wiley Online Library
Objective To compare the efficacy and safety of adalimumab plus methotrexate (MTX)
versus MTX monotherapy or adalimumab monotherapy in patients with early, aggressive …
versus MTX monotherapy or adalimumab monotherapy in patients with early, aggressive …
Long term efficacy and safety of adalimumab plus methotrexate in patients with rheumatoid arthritis: ARMADA 4 year extended study
ME Weinblatt, EC Keystone, DE Furst… - Annals of the …, 2006 - ard.bmj.com
Objective: To evaluate the efficacy and safety of adalimumab plus methotrexate (MTX) given
for up to 4 years in patients with active, longstanding rheumatoid arthritis. Methods: Patients …
for up to 4 years in patients with active, longstanding rheumatoid arthritis. Methods: Patients …
Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial
GR Burmester, AJ Kivitz, H Kupper… - Annals of the …, 2015 - ard.bmj.com
Objective CONCERTO was a randomised, double-blind, parallel-armed study of
methotrexate (MTX) in combination with adalimumab to assess whether an increasing trend …
methotrexate (MTX) in combination with adalimumab to assess whether an increasing trend …
Less radiographic progression with adalimumab plus methotrexate versus methotrexate monotherapy across the spectrum of clinical response in early rheumatoid …
P Emery, MC Genovese… - The Journal of …, 2009 - jrheum.org
Objective. To determine the relationship between radiographic progression and clinical
response for adalimumab plus methotrexate (MTX) versus either monotherapy in patients …
response for adalimumab plus methotrexate (MTX) versus either monotherapy in patients …
Disease activity, physical function, and radiographic progression after longterm therapy with adalimumab plus methotrexate: 5-year results of PREMIER
D van der HEIJDE, FC Breedveld… - The Journal of …, 2010 - jrheum.org
Objective. To evaluate the efficacy and safety of initial combination treatment with
adalimumab (ADA) and methotrexate (MTX) versus monotherapy with ADA or MTX during …
adalimumab (ADA) and methotrexate (MTX) versus monotherapy with ADA or MTX during …
Clinical, functional and radiographic consequences of achieving stable low disease activity and remission with adalimumab plus methotrexate or methotrexate alone …
A Kavanaugh, RM Fleischmann, P Emery… - Annals of the …, 2013 - ard.bmj.com
Objective To assess the efficacy and safety of adalimumab plus methotrexate (ADA+ MTX)
compared with methotrexate monotherapy in achieving stable low disease activity (LDA; …
compared with methotrexate monotherapy in achieving stable low disease activity (LDA; …
Adalimumab, a fully human anti–tumor necrosis factor α monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the …
ME Weinblatt, EC Keystone, DE Furst… - Arthritis & …, 2003 - Wiley Online Library
Objective To evaluate the efficacy and safety of adalimumab (D2E7), a fully human
monoclonal tumor necrosis factor α antibody, in combination with methotrexate (MTX) in …
monoclonal tumor necrosis factor α antibody, in combination with methotrexate (MTX) in …
Validation of the methotrexate‐first strategy in patients with early, poor‐prognosis rheumatoid arthritis: results from a two‐year randomized, double‐blind trial
Objective Methotrexate (MTX) taken as monotherapy is recommended as the initial disease‐
modifying antirheumatic drug for rheumatoid arthritis (RA). The purpose of this study was to …
modifying antirheumatic drug for rheumatoid arthritis (RA). The purpose of this study was to …
Evaluation of two strategies (initial methotrexate monotherapy vs its combination with adalimumab) in management of early active rheumatoid arthritis: data from the …
M Soubrier, X Puechal, J Sibilia, X Mariette… - …, 2009 - academic.oup.com
Objectives. In early and active RA despite MTX, continuous treatment with TNF blockers in
combination with MTX is recommended. To compare this strategy with an initial combination …
combination with MTX is recommended. To compare this strategy with an initial combination …
Efficacy, pharmacokinetic, and safety assessment of adalimumab, a fully human anti-tumor necrosis factor-alpha monoclonal antibody, in adults with rheumatoid …
MH Weisman, LW Moreland, DE Furst, ME Weinblatt… - Clinical …, 2003 - Elsevier
Background: Because traditional therapies for rheumatoid arthritis (RA) such as
methotrexate (MTX) do not produce an adequate response in many patients, newer …
methotrexate (MTX) do not produce an adequate response in many patients, newer …
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