The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds
M Kobayashi, L Li, N Iwamoto… - … and cellular biology, 2009 - Am Soc Microbiol
Animals have evolved defense systems for surviving in a chemically diverse environment.
Such systems should demonstrate plasticity, such as adaptive immunity, enabling a …
Such systems should demonstrate plasticity, such as adaptive immunity, enabling a …
[HTML][HTML] The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
T Nguyen, P Nioi, CB Pickett - Journal of biological chemistry, 2009 - ASBMB
A major mechanism in the cellular defense against oxidative or electrophilic stress is
activation of the Nrf2-antioxidant response element signaling pathway, which controls the …
activation of the Nrf2-antioxidant response element signaling pathway, which controls the …
Identification of the interactive interface and phylogenic conservation of the Nrf2‐Keap1 system
M Kobayashi, K Itoh, T Suzuki, H Osanai… - Genes to …, 2002 - Wiley Online Library
Abstract Background: The transcription factor Nrf2 and its negative regulator Keap1 play
important roles in transcriptional induction of a set of detoxifying and anti‐oxidant enzymes …
important roles in transcriptional induction of a set of detoxifying and anti‐oxidant enzymes …
Nrf2, a multi‐organ protector?
JM Lee, J Li, DA Johnson, TD Stein, AD Kraft… - The FASEB …, 2005 - Wiley Online Library
ABSTRACT NF‐E2‐related factor 2 (Nrf2) is a basic leucine zipper transcription factor that
binds to the promoter sequence “antioxidant responsive element (ARE)” leading to …
binds to the promoter sequence “antioxidant responsive element (ARE)” leading to …
Roles of Nrf2 in cell proliferation and differentiation
S Murakami, H Motohashi - Free Radical Biology and Medicine, 2015 - Elsevier
Abstract The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …
[HTML][HTML] The Nrf2 system as a potential target for the development of indirect antioxidants
KA Jung, MK Kwak - Molecules, 2010 - mdpi.com
Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …
lipids, and is implicated in various human diseases including cancer, neurodegeneration …
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
K Takaya, T Suzuki, H Motohashi, K Onodera… - Free Radical Biology …, 2012 - Elsevier
The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and
reactive oxygen species. Keap1 possesses a number of cysteine residues, some of which …
reactive oxygen species. Keap1 possesses a number of cysteine residues, some of which …
Mechanistic studies of the Nrf2-Keap1 signaling pathway
DD Zhang - Drug metabolism reviews, 2006 - Taylor & Francis
Since eukaryotic cells constantly encounter various environmental insults, they have
evolved defense mechanisms to cope with toxicant-and carcinogen-induced oxidative stress …
evolved defense mechanisms to cope with toxicant-and carcinogen-induced oxidative stress …
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
K Itoh, N Wakabayashi, Y Katoh, T Ishii… - Genes & …, 1999 - genesdev.cshlp.org
Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …
[HTML][HTML] Molecular mechanism of cellular oxidative stress sensing by Keap1
T Suzuki, A Muramatsu, R Saito, T Iso, T Shibata… - Cell reports, 2019 - cell.com
Summary The Keap1-Nrf2 system plays a central role in the oxidative stress response;
however, the identity of the reactive oxygen species sensor within Keap1 remains poorly …
however, the identity of the reactive oxygen species sensor within Keap1 remains poorly …