Animals have evolved defense systems for surviving in a chemically diverse environment.
Such systems should demonstrate plasticity, such as adaptive immunity, enabling a …

A major mechanism in the cellular defense against oxidative or electrophilic stress is
activation of the Nrf2-antioxidant response element signaling pathway, which controls the …

Abstract Background: The transcription factor Nrf2 and its negative regulator Keap1 play
important roles in transcriptional induction of a set of detoxifying and anti‐oxidant enzymes …

Abstract The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …

Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …

ABSTRACT NF‐E2‐related factor 2 (Nrf2) is a basic leucine zipper transcription factor that
binds to the promoter sequence “antioxidant responsive element (ARE)” leading to …

The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and
reactive oxygen species. Keap1 possesses a number of cysteine residues, some of which …

Since eukaryotic cells constantly encounter various environmental insults, they have
evolved defense mechanisms to cope with toxicant-and carcinogen-induced oxidative stress …

Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …

Summary The Keap1-Nrf2 system plays a central role in the oxidative stress response;
however, the identity of the reactive oxygen species sensor within Keap1 remains poorly …