EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma
J Lu, M Tang, H Li, Z Xu, X Weng, J Li, X Yu, L Zhao… - Cancer letters, 2016 - Elsevier
We conducted this research to explore the role of latent membrane protein 1 (LMP1)
encoded by the Epstein–Barr virus (EBV) in modulating the DNA damage response (DDR) …
encoded by the Epstein–Barr virus (EBV) in modulating the DNA damage response (DDR) …
Regulation of DNA damage signaling and cell death responses by Epstein-Barr virus latent membrane protein 1 (LMP1) and LMP2A in nasopharyngeal carcinoma …
Nasopharyngeal carcinoma (NPC) is closely associated with latent Epstein-Barr virus (EBV)
infection. Although EBV infection of preneoplastic epithelial cells is not immortalizing, EBV …
infection. Although EBV infection of preneoplastic epithelial cells is not immortalizing, EBV …
Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-κB regulated ATM expression
X Ma, L Yang, L Xiao, M Tang, L Liu, Z Li, M Deng… - PLoS …, 2011 - journals.plos.org
Background The latent membrane protein 1 (LMP1) encoded by EBV is expressed in the
majority of EBV-associated human malignancies and has been suggested to be one of the …
majority of EBV-associated human malignancies and has been suggested to be one of the …
LMP1‐positive extracellular vesicles promote radioresistance in nasopharyngeal carcinoma cells through P38 MAPK signaling
Z Zhang, X Yu, Z Zhou, B Li, J Peng, X Wu… - Cancer …, 2019 - Wiley Online Library
Radioresistance has been one of the impediments to effective nasopharyngeal carcinoma
(NPC) therapy in clinical settings. Epstein‐Barr virus (EBV) encoded latent membrane …
(NPC) therapy in clinical settings. Epstein‐Barr virus (EBV) encoded latent membrane …
Targeting EBV-LMP1 DNAzyme enhances radiosensitivity of nasopharyngeal carcinoma cells by inhibiting telomerase activity
L Yang, Z Xu, L Liu, X Luo, J Lu, L Sun… - Cancer biology & …, 2014 - Taylor & Francis
The latent membrane protein 1 (LMP1), which is encoded by the Epstein–Barr virus (EBV),
has been suggested to be one of the major oncogenic factors in nasopharyngeal carcinoma …
has been suggested to be one of the major oncogenic factors in nasopharyngeal carcinoma …
DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma
ZX Lu, XQ Ma, LF Yang, ZL Wang, L Zeng, ZJ Li, XN Li… - Cancer letters, 2008 - Elsevier
Epstein-Barr virus (EBV) is involved in the carcinogenesis of several types of cancers such
as nasopharyngeal carcinoma (NPC) and Burkitt's lymphoma. The latent membrane protein …
as nasopharyngeal carcinoma (NPC) and Burkitt's lymphoma. The latent membrane protein …
Epstein–Barr virus latent membrane protein 1 induces micronucleus formation, represses DNA repair and enhances sensitivity to DNA-damaging agents in human …
MT Liu, YR Chen, SC Chen, CY Hu, CS Lin, YT Chang… - Oncogene, 2004 - nature.com
The latent membrane protein 1 (LMP1) of Epstein–Barr virus (EBV) is a viral oncogene and it
is essential for the transformation of resting B cells by the virus. The protein acts as a ligand …
is essential for the transformation of resting B cells by the virus. The protein acts as a ligand …
[HTML][HTML] EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma
L Yang, L Liu, Z Xu, W Liao, D Feng, X Dong, S Xu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
LMP1, which is encoded by the Epstein-Barr virus, is proposed to be one of the major
oncogenic factors involved in nasopharyngeal carcinoma (NPC). Previous studies …
oncogenic factors involved in nasopharyngeal carcinoma (NPC). Previous studies …
Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated …
CF Yang, LX Peng, TJ Huang, GD Yang, QQ Chu… - Cancer letters, 2014 - Elsevier
Emerging evidence confirms that cancer stem cells (CSCs) are responsible for the
chemoradioresistance of malignancies. EBV-encoded latent membrane protein 1 (LMP1) is …
chemoradioresistance of malignancies. EBV-encoded latent membrane protein 1 (LMP1) is …
Silencing of LMP1 induces cell cycle arrest and enhances chemosensitivity through inhibition of AKT signaling pathway in EBV-positive nasopharyngeal carcinoma …
The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is closely associated with
nasopharyngeal carcinoma (NPC). In this study, we investigated that the effect of silencing …
nasopharyngeal carcinoma (NPC). In this study, we investigated that the effect of silencing …
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