Previous reports suggest that a type II iodothyronine 5'-deiodinase may become the main
enzymatic pathway for extrathyroidal triiodothyronine (T3) generation when the enzyme …

Homogenates of rat brown adipose tissue (BAT) and epididymal fat pad (EPI) catalyze the 5'-
deiodination of 3, 3′, 5′-triiodothyronine (rT3) in the presence of dithiothreitol. BAT, but …

Thyroxine 5'-deiodinase (type II) is present in a microsomal fraction of brown adipose tissue
(BAT) of Syrian hamsters. Cold exposure increased specific activity in homogenates after a …

We measured thyroxine 5'-deiodinase I (T (4) 5'DI) activity in thyroid, liver, and kidney and
thyroxine 5'-deiodinase II (T (4) 5'D-II) activity in brown adipose tissue (BAT) in rats on a low …

Thyroxine (T4) and reverse triiodothyronine are potent inhibitors of brown adipose T4 5'-
deiodinase (BAT 5'D). This effect does not require protein synthesis and is due to an …

Brown adipose tissue (BAT) is the major thermogenic organ of the human neonate. To
determine whether it is also active in the peripheral conversion of T4 to T3, as shown in …

Norepinephrine, isoproterenol, insulin, and glucagon increase the type II (low Km)
iodothyronine 5'-deiodinase (5'-D) in the brown adipose tissue (BAT) of intact rats …

As judged by the response of uncoupling protein and key enzymes, brown adipose tissue
(BAT) is highly dependent upon the local generation of T3 catalyzed by the tissue type II T4 …

Propylthiouracil (PTU) in maximally inhibitory doses for liver and kidney iodothyronine 5'-
deiodinase activity (5'DI), reduces extrathyroidal T4 to T3 conversion by only 60-70% in …

To provide new insights into the in vivo regulation of iodothyronine deiodinases in the
different tissues of the rat, we have evaluated the effects on these enzymatic activities of T4 …