The enzymatic activity in rat kidney homogenates mediating the conversion of T4 to T3 has
been previously shown to be particulate. The subcellular organelle responsible for T4 5 …

We have studied the origin of tri-iodothyronine (T 3) secreted by human and sheep
thyrocytes in primary culture and also the expression of type-I thyroidal iodothyronine …

To further understand the regulation of type II iodothyronine 5′-deiodinase (5′ D-II) in the
central nervous system and pituitary, we examined the response of this enzyme to the acute …

Two types of iodothyronine 5′-deiodination have been characterized previously in rat
tissues. They can be distinguished by inhibition of type I but not type II by 6-npropylthiouracil …

This study describes the existence of a peripheral tissue mechanism for maintaining serum
T3 concentrations in states of T4 deficiency or excess in man. Serum T3 and T4 levels were …

In subjects with normal thyroid function only a minor part of circulating 3, 5, 3′-
triiodothyronine (T 3) originates directly from the thyroid; the majority is produced in the …

Triiodothyronine (T3) and thyroxine (T4) were measured by immunoassay in the serum and
thyroid hydrolysates of control (group A), mildly iodine-deficient (group B), and severely …

In 9 euthyroid obese volunteers, 4 weeks of total caloric deprivation resulted in striking
decreases in both total and free triiodothyronine (T3) concentrations in serum together with a …

The local conversion of thyroxine (T4), which is an important source of intracellular 3, 5, 3'-
triiodothyronine (T3) in several rat tissues, has been subject of recent investigations. In the …

Studies were performed to assess the effects of thyroidectomy and hypophysectomy on the
overall metabolism of [125I] T4 and its conversion to [125I] T3. i in slices of rat liver and …