Hepatic monodeiodination of thyroxine (T 4), reverse triiodothyronine (rT 3), and
triiodothyronine (T 3) are enzymic reactions that depend on tissue concentrations of …

By using a highly specific radioimmunoassay the formation of tri-iodothyronine by the
deiodination of thyroxine was studied in rat liver homogenate. Several observations suggest …

Publisher Summary This chapter explores the metabolic pathways of thyroid hormones. In
vitro studies have been employed to study the nature of this peripheral regulatory …

This paper reports a radioimmunoassay method for triiodothyronine (T3) and the application
of this assay to the study of plasma and tissue T3 concentration in the rat. Several antisera …

To determine the influence of prolonged fasting and refeeding on rT3 metabolism in man,
five euthyroid obese subjects underwent a 13-day fast, followed by a refeeding period. Each …

Iodothyronine deiodinases, types I, II, and III (D1, D2, and D3) activities were measured in
tissues of fetal rats, at 18 and 21 days of gestation, at several levels of iodine deficiency (ID) …

MATERIALS AND METHODS Thyroidectomized and normal male rats, weighing
approximately 200 g, were purchased from Badger Research Corp., Madison, Wisconsin. All …

Previous studies have shown that norepinephrine causes a marked increase in the
iodothyronine 5′-deiodinase activity in dispersed brown adipocytes. This stimulation …

Studies were performed to explore the mechanism underlying the impaired generation of
125-I-3, 5, 3'-triiodothyronine (T3) from 125I-thyroxine (T4)(T3-neogenesis)) in preparations …

T4 5′-deiodinase, found in cell membranes of kidney and liver, is a thiol-dependent
enzyme inhibited by propylthiouracil (PTU). Pretreatment of enzymatically active kidney …