Topical Ophthalmic β‐Adrenergic Blockade for the Treatment of Glaucoma and Ocular Hypertension

WH Frishman, MS Fuksbrumer… - The Journal of Clinical …, 1994 - Wiley Online Library
Since the late 1970s, topical β‐adrenergic blockers have been the drugs of choice in
treating ocular hypertension and associated glaucoma. The currently available drugs are …

Ocular β-blockers in glaucoma management: clinical pharmacological aspects

AMV Brooks, WE Gillies - Drugs & aging, 1992 - Springer
Topical β-blockers reduce the intraocular pressure (IOP) by blockade of sympathetic nerve
endings in the ciliary epithelium causing a fall in aqueous humour production. Two types of …

Topical ophthalmic beta blockers: a comparative review

TJ ZIMMERMAN - Journal of Ocular Pharmacology and …, 1993 - liebertpub.com
Topically administered beta blockers are the preferred medical therapy for glaucoma. These
agents reduce intraocular pressure (IOP), thereby preventing damage to the optic nerve and …

The potential systemic effect of topically applied β-blockers in glaucoma therapy

T Taniguchi, Y Kitazawa - Current opinion in ophthalmology, 1997 - journals.lww.com
Although topical [beta]-blockers are generally tolerated, they can produce significant
systemic side effects. The systemic side effects of nonselective [beta]-blockers (eg, timolol …

Cardiovascular considerations in using topical, oral, and intravenous drugs for the treatment of glaucoma and ocular hypertension: focus on beta-adrenergic blockade.

WH Frishman, M Kowalski, S Nagnur… - Heart disease …, 2001 - europepmc.org
Glaucoma and ocular hypertension are highly prevalent conditions in individuals over the
age of 40 and are commonly seen together in patients with cardiovascular disease. Many of …

Carteolol, an ophthalmic β-adrenergic blocker with intrinsic sympathomimetic activity

WC Stewart - Journal of Glaucoma, 1994 - journals.lww.com
Timolol maleate, the first B-adrenergic antagonist available for the treatment of glaucoma
and ocular hypertension, was marketed in 1978 (1). Shortly after its introduction, systemic …

Comparison oftheocular beta-blockers

SJ Sorensen, SR Abel - Annals of Pharmacotherapy, 1996 - journals.sagepub.com
OBJECTIVE: To compare the similarities and differences among the ocular beta-blockers.
Important considerations when comparing these agents are the differences in systemic …

Systemic effects of topical ophthalmic β‐adrenoceptor antagonists

JL Rait - Australian and New Zealand journal of ophthalmology, 1999 - Wiley Online Library
Topical ophthalmic β‐adrenoceptor antagonists (beta‐blockers) are generally recognized as
the treatment of choice in glaucoma management due to favourable efficacy, safety and …

beta-Blockers and the eye: an overview.

IM Katz - Annals of Ophthalmology, 1978 - europepmc.org
Some beta-adrenoceptor blocking drugs are exciting new ocular hypotensive compounds.
Unlike pilocarpine, the mainstay of glaucoma treatment for the last 100 years, beta-blocking …

Systemic side effects of topical beta‐adrenergic blockers

WC Stewart, WP Castelli - Clinical Cardiology, 1996 - Wiley Online Library
Glaucoma, a disease that affects between 1 and 3% of the population above the age of 60,
is most commonly treated by topical beta‐adrenergic blockers. Although effective in lowering …