Two-layered dissolving microneedles (DMs) containing intermediate-acting insulin,
protamine sulfate insulin (PSI), were prepared. Then a pharmacodynamic study was …

Background: This study tested the hypothesis that dissolving microneedles are a useful
transdermal drug delivery system (TDDS) for insulin. Methods: Insulin was loaded on a …

Insulin loaded microneedles were prepared using dextrin as the base for the percutaneous
administration of insulin. Under room temperature, insulin solution was added to high …

Microneedle technology relates to pharmacy, polymer chemistry and micromachining.
Microneedle can effectively deliver insulin into systemic circulation across the skin. This …

As a percutaneous delivery device, self-dissolving micropiles (SDMPs) composed of
chondroitin sulfate and insulin were prepared under room temperature from highly …

Background: The aim of this report was to develop a dissolving microneedle (DM)
application system, where 225–300 insulin-loaded DMs were formed on a chip. After the …

Two kinds of insulin were loaded into self-dissolving micropile array tip (following tip). Fully-
loaded tip (f-tip) and partially-loaded tip (p-tip) were prepared using chondroitin sulfate for …

This study presents a dissolving microneedle patch, composed of starch and gelatin, for the
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …

In order to increase the utilization rate of drug carried by microneedles and reduce waste, a
two-step casting method was proposed to fabricate tip-loaded dissolving microneedles in …

Dissolving microneedles (MNs) display high efficiency in delivering poorly permeable drugs
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …