Immunoinflammatory background of neuronal damage in stroke

A Tuttolomondo - International Journal of Molecular Sciences, 2023 - mdpi.com
Ischemic stroke is caused by a reduction in blood flow to the brain and is a major cause of
mortality and disability worldwide. Cerebral ischemia initiates a complex cascade of events …

Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches

CD Maida, RL Norrito, M Daidone… - International journal of …, 2020 - mdpi.com
One of the most important causes of neurological morbidity and mortality in the world is
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …

Neuroinflammation in post-ischemic neurodegeneration of the brain: friend, foe, or both?

R Pluta, S Januszewski, SJ Czuczwar - International Journal of Molecular …, 2021 - mdpi.com
One of the leading causes of neurological mortality, disability, and dementia worldwide is
cerebral ischemia. Among the many pathological phenomena, the immune system plays an …

Editorial [Hot Topic: Citokines and Inflammation Markers in Ischemic Stroke (Executive Editor: Antonino Tuttolomondo)]

A Tuttolomondo - Current Pharmaceutical Design, 2008 - ingentaconnect.com
Interest in neuroimmunology and the actions of cytokines in the brain has grown
exponentially over the last decade. Cytokines represent a large and rapidly growing group …

Cerebral stroke injury: the role of cytokines and brain inflammation

A Siniscalchi, L Gallelli, G Malferrari… - Journal of Basic and …, 2014 - degruyter.com
Stroke represents the most frequent cause of permanent disability in adults worldwide.
Cerebral ischemia triggers the pathological pathways of the ischemic cascade and causes …

The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke

H Pawluk, A Woźniak, G Grześk… - … interventions in aging, 2020 - Taylor & Francis
Stroke is currently one of the most common causes of death and disability in the world, and
its pathophysiology is a complex process, involving the oxidative stress and inflammatory …

Cellular and molecular mechanisms of sterile inflammation in ischaemic stroke

K Nakamura, T Shichita - The journal of biochemistry, 2019 - academic.oup.com
Cerebral inflammation is a promising therapeutic target for ischaemic stroke. After ischaemic
stroke, inflammatogenic self-molecules, which originate from damaged brain tissue due to …

Inflammatory and neuroimmunomodulatory changes in acute cerebral ischemia

D Brea, T Sobrino, P Ramos-Cabrer… - Cerebrovascular …, 2009 - karger.com
Neuronal death produced by cerebral ischemia activates innate immunity by Toll-like
receptors and triggers inflammatory response. This response is necessary to remove cell …

Inflammation and inflammatory cell recruitment in acute cerebrovascular diseases

A Tuttolomondo, C Maida… - Current Immunology …, 2015 - ingentaconnect.com
Inflammation seems to play a major role in the pathogenesis of ischemic stroke as well as in
other forms of brain damage. Ischemic brain injury induces a strong inflammatory response …

Monocyte‐related cytokines/chemokines in cerebral ischemic stroke

M Bai, R Sun, B Cao, J Feng… - CNS Neuroscience & …, 2023 - Wiley Online Library
Aims Ischemic stroke is one of the leading causes of death worldwide and the most common
cause of disability in Western countries. Multiple mechanisms contribute to the development …