T helper (Th) 17 cells are responsible for host defense against fungi and certain extracellular
bacteria but have also been reported to play a role in a variety of autoimmune diseases …

The discovery of the T helper (Th) 17 lineage, involved in the protection against fungal and
extracellular bacterial infections, has profoundly revolutionized our current understanding of …

Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis
(MS) that shares many features with the human disease. This review will focus on the role of …

Until recently, autoimmune diseases had been categorized as either Th1-or Th2-mediated
diseases. However, the discovery of a novel subset of helper T cells producing interleukin …

Multiple sclerosis is a T cell-mediated demyelinating disease of the central nervous system.
Interleukin-17-producing T helper cells, named Th17 cells, represent a novel CD4+ T cell …

Interleukin‐17 (IL‐17) induces the production of granulocyte colony‐stimulating factor (G‐
CSF) and chemokines such as CXCL1 and CXCL2 and is a cytokine that acts as an …

The development of Th17 cells is a key event in the pathogenesis of experimental
autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis (MS) …

Th17 cells and their proinflammatory signature cytokine, IL-17, have recently replaced Th1
cells to be the essential Th effector population in autoimmune disease. This was based on a …

Abstract Lately, IL-17-secreting Th cells have received an overwhelming amount of attention
and are now widely held to be the major pathogenic population in autoimmune diseases. In …

It has been firmly established that IL-23 polarized TH17 cells are potent effectors in the
pathogenesis of experimental autoimmune encephalitomyelitis (EAE). However, the relative …