Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

With recent advances in methods of islet isolation and the introduction of more potent and
less diabetogenic immunosuppressive therapies, islet transplantation has progressed from …

Clinical pancreatic islet transplantation can be considered one of the safest and least
invasive transplant procedures. Remarkable progress has occurred in both the technical …

Pancreatic islet transplantation provides an effective treatment option for patients with type 1
diabetes (T1D) with intractable impaired awareness of hypoglycemia and severe …

Hypothesis A local multiorgan donor pancreas procurement program can provide a source
for optimized isolation of purified viable islets for transplantation into patients with type 1 …

Despite substantial advances in islet isolation methods and immunosuppressive protocol,
pancreatic islet cell transplantation remains an experimental procedure currently limited to …

Although pancreas transplantation is increasingly being performed in an effort to provide
type 1 diabetic patients with the possibility of an insulin-injection–free existence, islet …

Cell therapy for Type 1 diabetes (T1D) utilizing islet cell transplantation can successfully
restore endogenous insulin production in affected patients. Islet cell engraftment and …

Diabetes is a complex disease that affects over 400 million people worldwide. The life-long
insulin injections and continuous blood glucose monitoring required in type 1 diabetes …

Milestones in the history of diabetes therapy include the discovery of insulin and successful
methods of beta cell replacement including whole pancreas and islet cell transplantation …