Recent advances in sequencing technologies and collaborative efforts have led to
substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS) …

Abstract Purpose of Review Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-
FTD) spectrum disorder is a rare fatal disease with strong genetic influences. The …

The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift
as the number of genes associated with the disease risk and pathogenesis, and the cellular …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease predominantly affecting
upper and lower motor neurons. The disease leads to relentlessly progressive weakness of …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of motor neurons in the brain and spinal cord. The causes of ALS are not fully …

Amyotrophic lateral sclerosis (ALS) is a lethal degenerative disorder of motoneurons, which
may occur concurrently with frontotemporal dementia. Genetic analyses of the∼ 10% of ALS …

Amyotrophic lateral sclerosis (ALS) is the most prominent motor neuron disease in humans.
Its etiology consists of progressive motor neuron degeneration resulting in a rapid decline in …

The field of ALS continues to develop rapidly with multiple disease gene discoveries per
year. The relevance of these findings for genetic counseling and diagnosis is obvious. With …

The genetic architecture of amyotrophic lateral sclerosis (ALS) is being increasingly
understood. In this far-reaching review, we examine what is currently known about ALS …