As with most medical and pharmacologic interventions, mechanical ventilation must be
titrated within a therapeutic window, providing the required lifesustaining support while …

Once upon a time the existence of ventilator-induced lung injury (VILI) was debated. After all,
most patients with lung dysfunction requiring mechanical ventilation had other potential …

Mechanical ventilation has been used to support acutely ill patients for several decades. But
clinicians are aware that, despite the life-saving potential of this assistance, it has several …

Mechanical ventilation has become an indispensable tool, facilitating general anaesthesia
and supporting life in the critically ill. However, its application has adverse effects including …

Since its introduction into the management of the acute respiratory distress syndrome,
mechanical ventilation has been so strongly interwoven with its side effects that it came to be …

It is well established that mechanical ventilation can injure the lung, producing an entity
known as ventilator-induced lung injury (VILI). There are various forms of VILI, including …

The pathophysiological mechanisms by which mechanical ventilation can contribute to lung
injury, termed “ventilator-induced lung injury”(VILI), is increasingly well understood.“ …

Mechanical ventilation can produce lung physiological and morphological alterations
termed ventilator-induced lung injury (VILI). Early experimental studies demonstrated that …

Ventilator-induced lung injury (VILI) results from injury to the blood-gas barrier caused by
mechanical ventilation. The determinants of VILI are more complex than originally thought …

Protective ventilation strategies for the injured lung currently revolve around the use of low
Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase …