The dynamic roles of intracellular lipid droplets: from archaea to mammals

DJ Murphy - Protoplasma, 2012 - Springer
During the past decade, there has been a paradigm shift in our understanding of the roles of
intracellular lipid droplets (LDs). New genetic, biochemical and imaging technologies have …

[HTML][HTML] Lipid droplet proteins and metabolic diseases

S Xu, X Zhang, P Liu - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Lipid droplets (LDs) are ubiquitous cellular organelles for lipid storage which are composed
of a neutral lipid core bounded by a protein decorated phospholipid monolayer. Although …

Lipid droplets in health and disease

G Onal, O Kutlu, D Gozuacik… - Lipids in health and …, 2017 - Springer
Lipids are essential building blocks synthesized by complex molecular pathways and
deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found …

Lipid droplets and cellular lipid metabolism

TC Walther, RV Farese Jr - Annual review of biochemistry, 2012 - annualreviews.org
Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the
aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores …

Lipid droplet dynamics in budding yeast

CW Wang - Cellular and molecular life sciences, 2015 - Springer
Eukaryotic cells store excess fatty acids as neutral lipids, predominantly triacylglycerols and
sterol esters, in organelles termed lipid droplets (LDs) that bulge out from the endoplasmic …

[HTML][HTML] Lipid droplets: a dynamic organelle moves into focus

M Beller, K Thiel, PJ Thul, H Jäckle - FEBS letters, 2010 - Elsevier
Lipid droplets (LDs) were perceived as static storage deposits, which passively participate in
the energy homeostasis of both cells and entire organisms. However, this view has changed …

Mechanisms of lipid droplet biogenesis

KD Chapman, M Aziz, JM Dyer… - Biochemical Journal, 2019 - portlandpress.com
Lipid droplets (LDs) are organelles that compartmentalize nonbilayer-forming lipids in the
aqueous cytoplasm of cells. They are ubiquitous in most organisms, including in animals …

Not just fat: the structure and function of the lipid droplet

T Fujimoto, RG Parton - Cold Spring Harbor perspectives …, 2011 - cshperspectives.cshlp.org
Lipid droplets (LDs) are independent organelles that are composed of a lipid ester core and
a surface phospholipid monolayer. Recent studies have revealed many new proteins …

Cytosolic lipid droplets: from mechanisms of fat storage to disease

DA Gross, DL Silver - Critical reviews in biochemistry and …, 2014 - Taylor & Francis
The lipid droplet (LD) is a phylogenetically conserved organelle. In eukaryotes, it is born
from the endoplasmic reticulum, but unlike its parent organelle, LDs are the only known …

Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites

A Pol, SP Gross, RG Parton - Journal of Cell Biology, 2014 - rupress.org
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all
eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and …