To investigate the role of C5a generated on complement activation in brain, the lupus model,
MRL/lpr mice were treated with C5a receptor (R) antagonist (ant). Neutrophil infiltration …

Complement activation is an important aspect of systemic lupus erythematosus. In this study
we investigated the role of C3a/C3a receptor (R) signaling in brains of the lupus model …

In our earlier results, we demonstrated that cells expressing the complement C5aR are
vulnerable since abnormal activation of C5aR caused apoptosis of these cells. In this study …

J. Neurochem.(2011) 119, 1041–1051. Abstract Inflammation is a key factor in a number of
neurodegenerative diseases including systemic lupus erythematosus. The complement …

The blood-brain barrier (BBB) is a crucial anatomic location in the brain. Its dysfunction
complicates many neurodegenerative diseases, from acute conditions, such as sepsis, to …

OBJECTIVE: To discuss the effect of complement C52 (C5a) and complement C5a receptor
(C5aR) antagonists on inflammatory status of mouse microglial cells. MATERIALS AND …

The C3aR is expressed throughout the CNS and is increased in expression on glial cells
during CNS inflammation. However, the role that C3a and the C3aR play in chronic …

Soluble C5b-9 has been described as a pro-inflammatory mediator that triggers cell
activation rather than inducing cell death. Microglia is the most important immune cell …

Background Alzheimer's disease (AD) is a neurodegenerative dementia characterized by
the decline of cognition and the presence of neuropathological changes including neuronal …

Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …