In order to survive within the macrophages of its host organism, the protozoan parasite
Leishmania inhibits a number of critical, gamma interferon (IFN-γ)-inducible, macrophage …

Activation of host phosphotyrosine phosphatase SHP‐1 by Leishmania and its subsequent
impact on tyrosine phosphorylation‐based signaling cascades were shown to represent an …

Modulation of the phagocyte protein tyrosine phosphatase (PTP) SHP‐1 by the parasite
Leishmania favors its survival and propagation within its mammalian host. In vivo, the …

The human leishmaniasis are persistent infections of macrophages caused by protozoa of
the genus Leishmania. The chronic nature of these infections is in part related to induction of …

Protozoan parasites of the genus leishmania are obligate intracellular parasites of
monocytes and macrophages. These pathogens have evolved to invade the mammalian …

Leishmania parasites are able to secure their survival and propagation within their host by
altering signalling pathways involved in the ability of macrophages to kill pathogens or to …

Nitric oxide (NO) is a potent molecule involved in the cytotoxic effects mediated by
macrophages (MØ) against microorganisms. We previously reported that Src homology 2 …

Leishmania‐induced macrophage (Mϕ) dysfunctions have been correlated with altered
signaling events. Recent findings from our laboratory suggest that modulation of host protein …

Activation of the Janus-activated kinase 2 (JAK2)/STAT1α signaling pathway is repressed in
Leishmania-infected macrophages. This represents an important mechanism by which this …

The protozoa Leishmania spp. are obligate intracellular parasites that inhabit the
macrophages of their host. Since macrophages are specialized for the identification and …