Glioblastoma multiforme (GBM), a prevalent brain cancer with high mortality, is resistant to
the conventional single-agent chemotherapy. In this study, we employed a combination …

Aim: Anticancer drug-loaded hydrogels are a promising strategy for the local treatment of
incurable brain tumors such as glioblastoma (GBM). Recently, we demonstrated the efficacy …

Lauroyl-gemcitabine lipid nanocapsules (GemC 12-LNC) hydrogel, administered
intratumorally or perisurgically in the tumor resection cavity, increases animal survival in …

Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumor in human. 17-Allylamino-17-demethoxy geldanamycin (17-AAG) is an inhibitor of heat …

Glioblastoma (GBM) recurrences are inevitable, and mainly originate from residual tumor
cells and the presence of glioma stem cells (GSC) around the resection cavity borders. We …

Glioblastoma (GBM) treatment includes, when possible, surgical resection of the tumor
followed by radiotherapy and oral chemotherapy with temozolomide, however recurrences …

In decades, the efficiency of glioma therapy is far from satisfaction due to the inability of most
therapeutics to accumulate at the glioblastoma (GBM) site. Therefore, it is urgent to develop …

Glioblastoma multiforme (GBM) is one of the most common and malignant tumor. Luteolin, a
polyphenolic compound, has been proposed to have anti-tumor activity against various …

The local delivery of chemotherapeutic agents is a very promising strategy for the treatment
of glioblastoma (GBM). Gemcitabine is a chemotherapeutic agent that has a different …

The efficacy of standard glioblastoma (GBM) treatments has been limited due to the highly
immunosuppressive tumor immune microenvironment, interpatient tumor heterogenicity and …