The present paper proposes a model for the identification and the validation of brain
processes and mechanisms underlying smokers' cue reactivity. Smoking behaviour is …

Basic neuroscience research conducted over the last quarter century has provided us with
much information concerning potential biobehavioral and neuromolecular mechanisms …

A major goal of basic nicotine research is to obtain information useful to the clinician in
determining why and how people become dependent on this substance via the use of …

Nicotine is a psychoactive ingredient in tobacco that significantly contributes to the harmful
tobacco smoking habit. Nicotine dependence is more prevalent than dependence on any …

BACKGROUND: Cue reactivity, the ability of cues associated with addictive substances to
induce seeking and withdrawal, is a major contributor to addiction. Although human imaging …

Over the last 20 years much progress has been made in understanding the pharmacologic
basis of tobacco addiction. In particular, the role of nicotine in reinforcing smoking behavior …

This chapter considers the neurobiological mechanisms that are thought to mediate the
reinforcing or rewarding properties of nicotine. It focuses on the data (derived principally …

Tobacco smoking is the most frequent form of substance abuse. We provide a review of the
neuroadaptive changes evidenced in human smokers with regard to the current …

OBJECTIVE: Nicotine is a highly addictive substance, and cigarette smoking is a major
cause of premature death among humans. Little is known about the neuropharmacology …

Nicotine, the primary psychoactive component of tobacco smoke, produces diverse
neurophysiological, motivational and behavioural effects through several brain regions and …