Plasma osteopontin levels in multiple sclerosis
M Comabella, I Pericot, R Goertsches, C Nos… - Journal of …, 2005 - Elsevier
Osteopontin (OPN) is a pleiotropic integrin binding protein with functions in cell-mediated
immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN …
immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN …
Osteopontin levels and increased disease activity in relapsing–remitting multiple sclerosis patients
MHJ Vogt, S Floris, J Killestein, DL Knol, M Smits… - Journal of …, 2004 - Elsevier
Osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene
expressed within multiple sclerosis (MS) lesions. Recently, we demonstrated that OPN …
expressed within multiple sclerosis (MS) lesions. Recently, we demonstrated that OPN …
Elevated osteopontin levels in active relapsing‐remitting multiple sclerosis
MHJ Vogt, L Lopatinskaya, M Smits… - Annals of …, 2003 - Wiley Online Library
In the search for proteins that might play a role in the pathogenesis of multiple sclerosis
(MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene …
(MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene …
Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica
Y Shimizu, K Ota, R Ikeguchi, S Kubo… - Journal of …, 2013 - Elsevier
Osteopontin (OPN) up-regulates pro-inflammatory cytokines from both T helper type 1 and T
helper type 17 cell pathways. We measured plasma OPN levels in Japanese multiple …
helper type 17 cell pathways. We measured plasma OPN levels in Japanese multiple …
Osteopontin concentrations are increased in cerebrospinal fluid during attacks of multiple sclerosis
L Börnsen, M Khademi, T Olsson… - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background: The cytokine osteopontin (OPN) is a potential key player in the
immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease …
immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease …
The role of osteopontin in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS)
M Braitch, CS Constantinescu - Inflammation & Allergy-Drug …, 2010 - ingentaconnect.com
Osteopontin (OPN) is an extracellular matrix protein with chemokine, cytokine and integrin
properties. It has multiple immunological functions and is secreted by activated …
properties. It has multiple immunological functions and is secreted by activated …
Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development
P Kivisäkk, BC Healy, K Francois… - Multiple Sclerosis …, 2014 - journals.sagepub.com
Background: Osteopontin (OPN) is a pleiotropic protein with important roles in inflammation
and immunity that has been suggested as a candidate biomarker for disease activity in …
and immunity that has been suggested as a candidate biomarker for disease activity in …
Role of anti-osteopontin antibodies in multiple sclerosis and experimental autoimmune encephalomyelitis
N Clemente, C Comi, D Raineri, G Cappellano… - Frontiers in …, 2017 - frontiersin.org
Osteopontin (OPN) is highly expressed in demyelinating lesions in multiple sclerosis (MS)
and experimental autoimmune encephalomyelitis (EAE). OPN is cleaved by thrombin into N …
and experimental autoimmune encephalomyelitis (EAE). OPN is cleaved by thrombin into N …
Osteopontin gene haplotypes correlate with multiple sclerosis development and progression
A Chiocchetti, C Comi, M Indelicato, L Castelli… - Journal of …, 2005 - Elsevier
Osteopontin (OPN) is an inflammatory cytokine highly expressed in multiple sclerosis (MS)
plaques. In a previous work, we showed that four OPN polymorphisms form three haplotypes …
plaques. In a previous work, we showed that four OPN polymorphisms form three haplotypes …
Osteopontin: a key link between immunity, inflammation and the central nervous system
A Brown - Translational neuroscience, 2012 - Springer
Osteopontin (OPN) is a pro-inflammatory cytokine that can be secreted from many cells
including activated macrophages and T-lymphocytes. Elevated levels of osteopontin in the …
including activated macrophages and T-lymphocytes. Elevated levels of osteopontin in the …