Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …

For many decades, research on sphingolipids associated with neurodegenerative disease
focused on alterations in glycosphingolipids, particularly glycosylceramides (cerebrosides) …

Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to
being the precursor of complex sphingolipids, ceramides can act as second messengers …

Ceramide forms the backbone of all complex sphingolipids and has been the focus of
considerable attention in the past few years due to the discovery that ceramide plays vital …

Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …

Formerly considered to serve only as structural components, sphingolipids are emerging as
an important group of signaling molecules involved in many cellular events, including cell …

The public health burden of metabolic syndrome (MetS), a multiplex risk factor that arises
from insulin resistance accompanying abnormal adipose conditions, and Alzheimer's …

Background Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's
disease dementia (PDD), and frontotemporal lobar dementia (FTLD) are characterized by …

Ceramides have been implied in intracellular signal transduction systems regulating cellular
differentiation, activation, survival and apoptosis and thus appear capable of changing the …

Simple sphingolipids such as ceramide, sphingosine and sphingosine 1-phosphate are key
regulators of diverse cellular functions. Their roles in the nervous system are supported by …