A study was performed to determine the limiting factors to expanding the donor pool with
warm ischemically (WI) damaged kidneys. Canine kidneys were damaged by 30 min of WI …

For the past decades, severe hypothermia has represented the foundation of organ
preservation in clinical transplantation. Beneficial as hypothermia has proven to be in …

The effect of simple cold storage on ice with or without preceding warm ischemic injury on
the energy metabolism and posttransplant viability of canine kidneys was examined in the …

Background. In a recent trial, targeted mild hypothermia in brain-dead organ donors
significantly reduced the incidence of delayed graft function after kidney transplantation. This …

Background Delayed graft function, which is reported in up to 50% of kidney-transplant
recipients, is associated with increased costs and diminished long-term graft function. The …

Cold preservation sensitizes organ grafts to exacerbation of tissue injury upon reperfusion.
This reperfusion injury is not fully explained by the mere re-introduction of oxygen but rather …

Kidneys recovered from donation after cardiac death (DCD) are increasingly used to enlarge
the deceased donor pool. Such renal grafts, especially those derived from uncontrolled …

Background. The ability to effectively utilize kidneys damaged by severe (2 hr) warm
ischemia (WI) could provide increased numbers of kidneys for transplantation. The present …

The current shortage of transplantable organs has renewed interest in kidneys obtained
from non-heartbeating donors. Kidneys from these donors have suffered warm ischemia …

Especially in damaged organs, adequate organ preservation is critically important to
maintain viability. Institut Georges Lopez‐1 (IGL‐1) is a new preservation solution, with an …