The factors determining whether an immune response is productive are poorly understood.
To understand the circumstances affecting the early stage of the immune response which …

Memory T cells are derived directly from effector cells without need for additional antigen,
TcR triggering or induced cytokines. A large fraction of effectors can become memory cells …

Following a primary immune response, a portion of effector T cells gives rise to long-lived
memory cells. Although primary expansion and differentiation of effector CD8 T cells is …

Recent studies have demonstrated that viral and bacterial infections can induce dramatic in
vivo expansion of Ag-specific T lymphocytes. Although presentation of Ag is critical for …

The generation of memory T cells is critically important for rapid clearance and neutralization
of pathogens encountered previously by the immune system. We have studied the kinetics of …

Recent studies suggest that memory T-cell differentiation continues for weeks or months
following antigen clearance, although commitment to the memory lineage occurs during the …

The rules that govern memory T cell differentiation are not well understood. This study
shows that after antigenic stimulation naïve CD8+ T cells become committed to dividing at …

T Memory Cells: Quality not Quantity Dispatch Page 1 T Memory Cells: Quality not Quantity
Dispatch Jonathan Sprent Immunological memory to pathogens is associated with clonal …

Our T cell repertoire is shaped by antigen encounter. From a naive T cell pool that contains
millions of different T cells with unknown specificities, pathogen infection leads to selection …

Recent findings suggest a new paradigm that early inflammatory cytokines promote the
effector T‐cell response while inhibiting the development of CD8+ T‐cell memory. Although …