A major obstacle to the development of implantable biosensors is the foreign body response
(FBR) that results from tissue trauma during implantation and the continuous presence of the …

Background: Successful performance of implantable glucose biosensors for metabolic
monitoring is dependent on tissue compatibility. Negative immunostimulatory tissue …

Application of implantable glucose biosensors for “real-time” monitoring is reliant on
controlling the negative tissue reaction at the sensor tissue interphase. A novel polymer …

Background: Hydrogels alone and in combination with microsphere drug delivery systems
are being considered as biocompatible coatings for implantable glucose biosensors to …

Background: Continuous release of dexamethasone from PLGA microsphere/PVA hydrogel
composites has been shown to suppress the inflammatory tissue reaction in response to …

Background: Implantable biosensors for continuous glucose monitoring can greatly improve
diabetes management. However, their applications are still associated with some …

The foreign body reaction is the major cause of the dysfunction and relatively short lifetime
associated with implanted glucose biosensors. An effective strategy to maintain sensor …

Biofouling and tissue inflammation present major challenges toward the realization of long-
term implantable glucose sensors. Following sensor implantation, proteins and cells adsorb …

We have developed a new dexamethasone (Dex)‐loaded poly (lactic‐co‐glycolic acid)
microspheres/porous collagen scaffold composite for implantable glucose sensors. The …

The biological response to implanted biomaterials in mammals is a complex series of events
that involves many biochemical pathways. Shortly after implantation, fibrinogen and other …