[HTML][HTML] Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver
Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent, and potentially morbid,
disease that affects one-third of the US population. Normal liver safely accommodates lipid …
disease that affects one-third of the US population. Normal liver safely accommodates lipid …
[HTML][HTML] Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome
DA d'Avignon, P Puchalska, B Ercal, YJ Chang… - JCI insight, 2018 - ncbi.nlm.nih.gov
While several molecular targets are under consideration, mechanistic underpinnings of the
transition from uncomplicated nonalcoholic fatty liver disease (NAFLD) to nonalcoholic …
transition from uncomplicated nonalcoholic fatty liver disease (NAFLD) to nonalcoholic …
Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease
PK Luukkonen, S Dufour, K Lyu… - Proceedings of the …, 2020 - National Acad Sciences
Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic
fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite …
fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite …
[HTML][HTML] Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver
X Fu, JA Fletcher, S Deja… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Hepatic de novo lipogenesis (DNL) and β-oxidation are tightly coordinated,
and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver …
and their dysregulation is thought to contribute to the pathogenesis of nonalcoholic fatty liver …
[HTML][HTML] Emerging role of hepatic ketogenesis in fatty liver disease
RGR Mooli, SK Ramakrishnan - Frontiers in Physiology, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …
[HTML][HTML] Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia
DG Cotter, B Ercal, X Huang, JM Leid… - The Journal of …, 2014 - Am Soc Clin Investig
Nonalcoholic fatty liver disease (NAFLD) spectrum disorders affect approximately 1 billion
individuals worldwide. However, the drivers of progressive steatohepatitis remain …
individuals worldwide. However, the drivers of progressive steatohepatitis remain …
β-Hydroxybutyrate is reduced in humans with obesity-related NAFLD and displays a dose-dependent effect on skeletal muscle mitochondrial respiration in vitro
JT Mey, ML Erickson, CL Axelrod… - American Journal …, 2020 - journals.physiology.org
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation and
impaired insulin sensitivity. Reduced hepatic ketogenesis may promote these pathologies …
impaired insulin sensitivity. Reduced hepatic ketogenesis may promote these pathologies …
[HTML][HTML] Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease
PK Luukkonen, S Qadri, N Ahlholm, K Porthan… - Journal of …, 2022 - Elsevier
Background & Aims There is substantial inter-individual variability in the risk of non-alcoholic
fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR)('MetComp') …
fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR)('MetComp') …
[HTML][HTML] Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease
ES Selen, J Choi, MJ Wolfgang - JCI insight, 2021 - ncbi.nlm.nih.gov
To extract energy from stored lipids, fatty acids must first be liberated from triglyceride before
their β-oxidation in mitochondria in a coordinated and stepwise manner. To determine the …
their β-oxidation in mitochondria in a coordinated and stepwise manner. To determine the …
[HTML][HTML] Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance
EÁ Hernández, S Kahl, A Seelig… - The Journal of …, 2017 - Am Soc Clin Investig
Nonalcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of fat in
the liver. In some cases, NAFLD is also accompanied by insulin resistance, resulting in …
the liver. In some cases, NAFLD is also accompanied by insulin resistance, resulting in …