Ovarian cancer preferentially metastasizes to the omentum, a fatty tissue characterized by
immune structures called milky spots, but the cellular dynamics that direct this tropism are …

The goal of controlling ovarian cancer metastasis formation has elicited considerable
interest in identifying the tissue microenvironments involved in cancer cell colonization of the …

Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs)
play important roles in cancer progression. Here, we have characterized the ontogeny and …

Controlling metastases remains a critical problem in cancer biology. Within the peritoneal
cavity, omental tissue is a common site for metastatic disease arising from intraperitoneal …

The omentum is a visceral adipose tissue with unique immune functions. Although it is
primarily an adipose tissue, the omentum also contains lymphoid aggregates, called milky …

Metastasis is a multistep process requiring tumor cell detachment from the primary tumor
and migration to target organs through the lymphatic or blood circulatory systems. Specific …

The omentum, an important peritoneal tissue, is studded with a high number of immune
aggregates, or “milky spots,” the number, function, and phenotype of which is largely …

It is still a question of debate whether neutrophils, often found in the tumor
microenvironment, mediate tumor-promoting or rather tumor-inhibiting activities. The present …

Background: The greater omentum is frequently involved in the course of gastrointestinal
and ovarian tumors. Therefore, common practice in surgical treatment for especially gastric …

The tumor microenvironment is known to have a profound effect on tumor progression in a
highly context-specific manner. We have investigated whether peritoneal inflammation plays …