Nicotine exposure disrupts placental development via the Notch signaling pathway

QR Sun, DY Wu, JJ Zhang, LH Wu, X Zhang… - …, 2023 - rep.bioscientifica.com
In brief Normal gene expression during early embryonic development and in the placenta is
crucial for a successful pregnancy. Nicotine can disrupt normal gene expression during …

[PDF][PDF] Reduced placental size and increased apoptosis are associated with prenatal nicotine exposure in rats.

A Alzu'Bi, MS Al Zoubi, GT Abdelhady… - European Review for …, 2022 - europeanreview.org
OBJECTIVE: Smoking during pregnancy has been linked to a variety of negative embryonic
and neonatal consequences. Nicotine is the major constituent of tobacco smoke, which was …

Characterization of the adverse effects of nicotine on placental development: in vivo and in vitro studies

AC Holloway, A Salomon, MJ Soares… - American Journal …, 2014 - journals.physiology.org
In utero exposure to nicotine is associated with increased risk of numerous adverse fetal and
neonatal outcomes, which suggests that it acts directly to affect placental development and …

Nicotine‐induced embryonic malformations mediated by apoptosis from increasing intracellular calcium and oxidative stress

Z Zhao, EA Reece - Birth Defects Research Part B …, 2005 - Wiley Online Library
BACKGROUND: Tobacco smoking by women during pregnancy increases the risk of
congenital birth defects in the infants. Among the smoke products, nicotine is believed to be …

Adverse effects of perinatal nicotine exposure on reproductive outcomes

MK Wong, NG Barra, N Alfaidy, DB Hardy… - …, 2015 - rep.bioscientifica.com
Nicotine exposure during pregnancy through cigarette smoking, nicotine replacement
therapies or e-cigarette use continues to be a widespread public health problem, impacting …

Maternal nicotine exposure leads to impaired disulfide bond formation and augmented endoplasmic reticulum stress in the rat placenta

MK Wong, CJ Nicholson, AC Holloway, DB Hardy - PloS one, 2015 - journals.plos.org
Maternal nicotine exposure has been associated with many adverse fetal and placental
outcomes. Although underlying mechanisms remain elusive, recent studies have identified …

Impact of Prenatal Nicotine Exposure on Placental Function and Respiratory Neural Network Development

S Beltrán-Castillo, K Bravo, J Eugenín - Advances in Maternal-Fetal …, 2023 - Springer
Smoking during pregnancy is associated with multiple undesirable outcomes in infants, such
as low birth weight, increased neonatal morbidity and mortality, and catastrophic conditions …

Melatonin ameliorates murine fetal oocyte meiotic dysfunction in F1 and F2 offspring caused by nicotine exposure during pregnancy

WX Liu, SJ Tan, YF Wang, L Li, XF Sun, J Liu… - Environmental …, 2020 - Elsevier
Although there is abundant evidence to demonstrate that maternal smoking during
pregnancy will harm the health of future generations, the impact of nicotine use by pregnant …

The impact of tobacco chemicals and nicotine on placental development

MA Suter, KM Aagaard - Prenatal diagnosis, 2020 - Wiley Online Library
Despite decades of messages warning about the dangers of tobacco use in pregnancy, 10%
to 15% of pregnant women continue to smoke. Furthermore, an increased popularity of …

Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates

JO Lo, MC Schabel, VHJ Roberts, TK Morgan… - American journal of …, 2015 - Elsevier
Objective We previously demonstrated that prenatal nicotine exposure decreases neonatal
pulmonary function in nonhuman primates, and maternal vitamin C supplementation …