The first gerontological studies using two-dimensional gel electrophoresis (2DGE) were
frustating since it was very difficult, when not impossible, to identify the proteins for which an …

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The scope of the current paper is to review existing and potential applications of proteomic
analysis to aging research. The focus will lie on the unique opportunities of high-throughput …

The accumulation of non-enzymatic modifications on both DNA and protein molecules under
the attack of reactive oxygen species (ROS), is one of the most possible factors responsible …

Background: Aging is closely related to the onset of chronic diseases, such as coronary
artery disease, diabetic nephropathy or different types of malignancies, reflecting the …

This review covers the application of mass spectrometric techniques to aging research.
Modern proteomic strategies will be discussed as well as the targeted analysis of specific …

Aging is characterized by changes in a variety of cellular phenotypes, which in turn are
caused by alterations in the concentrations, compositions, and interactions of cellular …

This chapter describes protocols for two-dimensional (2D) gel electrophoresis (isoelectric
focusing [IEF] followed by sodium-dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis …

Based on demographic trends, the societies in many developed countries are facing an
increasing number and proportion of people over the age of 65. The raise in elderly …

Functional decline of tissues in aged animals is a result of cellular aging. Though any
process of somatic cell aging basically depends on genomic instructions, phenotypes of …