The nucleus of eukaryotic cells contains a distinct set of proteins necessary for the
management of genes. Following synthesis in the cytoplasm, proteins enter the nucleus …

Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment
that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS …

To enter the nucleus, a protein must transit through one of the largest and most complex
gateways in the eukary-otic cell, the nuclear pore. Consisting of perhaps 1000 proteins (60 …

Available data strongly suggest that simple karyophilic clusters of arginines and lysines in
nucleus-targeted proteins signal the anchoring of these proteins to specialized transporter …

Transport of proteins, RNAs and ribonucleoprotein particles into and out of the nucleus is
essential for many cellular functions to proceed. Recent progress in this area of research …

Several nuclear proteins, including steroid hormone receptors, have been shown to shuttle
continuously between the nucleus and the cytoplasm. The mechanism of entry of proteins …

Protein Import into the Nucleus: An Integrated View Page 1 AnnlL Rev. Cell Dev. Bioi. 1995.
11:J55...Jl8 Copyright Q 1995 by Annual Reviews Inc. All rights reserved PROTEIN IMPORT …

Nuclear protein transport has been the subject of considerable attexition as of late. In part,
this is due to the desire of researchers to contribute towards our knowledge of how proteins …

Signaling pathways consist of a chain of biochemical events that form the intracellular
equivalent of a fire bucket brigade. An initial change or chemical signal outside the cell is …

The past two years have seen a significant increase in our understanding of nuclear protein
import. Five cytosolic import factors have been identified, two of which have been shown to …