Are the pharmacology and physiology of α2adrenoceptors determined by α2‐heteroreceptors and autoreceptors respectively?

R Gilsbach, L Hein - British journal of pharmacology, 2012 - Wiley Online Library
α2‐Adrenoceptors are important mediators of physiological responses to the endogenous
catecholamines noradrenaline and adrenaline. In addition, α2‐adrenoceptors are …

α2-Adrenoceptor subtypes—Unexpected functions for receptors and ligands derived from gene-targeted mouse models

AE Knaus, V Muthig, S Schickinger, E Moura… - Neurochemistry …, 2007 - Elsevier
α2-Adrenoceptors belong to the group of nine adrenoceptors which mediate the biological
actions of the endogenous catecholamines adrenaline and noradrenaline. Studies with …

Genetic dissection of α2-adrenoceptor functions in adrenergic versus nonadrenergic cells

R Gilsbach, C Röser, N Beetz, M Brede… - Molecular …, 2009 - ASPET
α2-Adrenoceptors mediate diverse functions of the sympathetic system and are targets for
the treatment of cardiovascular disease, depression, pain, glaucoma, and sympathetic …

Subtypes of functional α1-and α2-adrenoceptors

JR Docherty - European journal of pharmacology, 1998 - Elsevier
In this review, subtypes of functional α1-and α2-adrenoceptors are discussed. These are cell
membrane receptors, belonging to the seven transmembrane spanning G-protein-linked …

Molecular Pharmacology of α2-adrenoceptor Subtypes

R Aantaa, A Marjamäki, M Scheinin - Annals of medicine, 1995 - Taylor & Francis
α2adrenergic receptors mediate many of the physiological actions of the endogenous
catecholamines adrenaline and noradrenaline, and are targets of several therapeutic …

Expression of α1-adrenoceptor subtypes in rat tissues: implications for α1-adrenoceptor classification

C Faure, C Pimoule, S Arbilla, SZ Langer… - European Journal of …, 1994 - Elsevier
We report here the mapping of the mRNA distribution of three different α 1-adrenoceptor
subtypes (α 1b, α 1c and α 1d) in various rat tissues. cDNA fragments covering the region …

α2-Adrenoceptor subtypes-mediated physiological, pharmacological actions

K Gyires, ZS Zádori, T Török, P Mátyus - Neurochemistry international, 2009 - Elsevier
α2-Adrenoceptors are involved in various physiological functions, particularly in the
cardiovascular system and the central nervous system. Different adrenoceptor subtypes …

Physiological significance of α2-adrenergic receptor subtype diversity: one receptor is not enough

M Philipp, M Brede, L Hein - American Journal of …, 2002 - journals.physiology.org
α2-Adrenergic receptors mediate part of the diverse biological effects of the endogenous
catecholamines epinephrine and norepinephrine. Three distinct subtypes of α2-adrenergic …

Pharmacologic characterization of cloned α1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype

DA Schwinn, JW Lomasney - European Journal of Pharmacology …, 1992 - Elsevier
In membranes prepared from Cos-7 or HeLa cells expressing one of three individual cloned
α 1-adrenoceptor subtypes, competition with 2-{(β-(4-hydroxy-3-[125 I] iodophenyl) …

Insights into α1 adrenoceptor function in health and disease from transgenic animal studies

A Tanoue, T Koshimizu, K Shibata, Y Nasa… - Trends in Endocrinology …, 2003 - cell.com
Abstract α 1-Adrenoceptors (ARs) mediate some of the main actions of the natural
catecholamines, epinephrine and norepinephrine, and have a crucial role in the regulation …