The specific cellular underpinnings or mechanisms of insulin resistance (IR) are not clear.
Here I present evidence to support a causal association between mitochondrial energetics …

The contribution of mitochondrial dysfunction to insulin resistance is a contentious issue in
metabolic research. Recent evidence implicates mitochondrial dysfunction as contributing to …

Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise
factors that lead to insulin resistance have not been elucidated fully, but there is a strong …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D) and is
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …

The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …

Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …

Diabetes profoundly alters fuel metabolism; both insulin deficiency and insulin resistance
are characterized by inefficient mitochondrial coupling and excessive production of reactive …