Glucose is the major fuel for fetal oxidative metabolism. A positive maternal–fetal glucose
gradient drives glucose across the placenta and is sufficient to meet the demands of the …

Fetal growth restriction (FGR) is accompanied by early activation of hepatic glucose
production (HGP), a hallmark of type 2 diabetes (T2D). Here, we used fetal hepatic …

Intrauterine growth restriction (IUGR) increases the risk for metabolic disease and diabetes,
although the developmental origins of this remain unclear. We measured glucose …

Intrauterine growth-restricted (IUGR) fetal sheep have increased hepatic glucose production
(HGP) that is resistant to suppression during a hyperinsulinemic-isoglycemic clamp (insulin …

Mild gestational hyperglycemia is often associated with fetal overgrowth that can predispose
the offspring to metabolic diseases later in life. We hypothesized that unfavorable …

Fetal glucose metabolism depends on additive effects of fetal plasma glucose and insulin.
Glucose-stimulated insulin secretion increases over gestation, is down-regulated by …

Expression of key metabolic genes and proteins involved in mRNA translation, energy
sensing, and glucose metabolism in liver and skeletal muscle were investigated in a late …

Placental insufficiency leads to intrauterine growth restriction (IUGR) and a lifelong risk of
developing type 2 diabetes. Impaired islet development in the growth restricted fetus …

We determined in vivo and in vitro pancreatic islet insulin secretion and glucose metabolism
in fetuses with intrauterine growth restriction (IUGR) caused by chronic placental …

Glucose is the principal energy substrate for the the fetus and is essential for normal fetal
metabolism and growth. Fetal glucose metabolism is directly dependent on the fetal plasma …