Interleukin‐1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel‐associated acute pain syndrome
Patients receiving paclitaxel for cancer treatment often develop an acute pain syndrome
(paclitaxel‐associated acute pain syndrome, P‐APS), which occurs immediately after …
(paclitaxel‐associated acute pain syndrome, P‐APS), which occurs immediately after …
Paclitaxel induces acute pain via directly activating toll like receptor 4
Paclitaxel, a powerful anti-neoplastic drug, often causes pathological pain, which
significantly reduces the quality of life in patients. Paclitaxel-induced pain includes pain that …
significantly reduces the quality of life in patients. Paclitaxel-induced pain includes pain that …
Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1
Background Paclitaxel is a widely used and potent chemotherapeutic agent for the treatment
of cancer. However, patients receiving paclitaxel often develop an acute pain syndrome for …
of cancer. However, patients receiving paclitaxel often develop an acute pain syndrome for …
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats
A Ledeboer, BM Jekich, EM Sloane… - Brain, behavior, and …, 2007 - Elsevier
Paclitaxel is a commonly used cancer chemotherapy drug that frequently causes painful
peripheral neuropathies. The mechanisms underlying this dose-limiting side effect are …
peripheral neuropathies. The mechanisms underlying this dose-limiting side effect are …
[HTML][HTML] Evidence that spinal astrocytes but not microglia contribute to the pathogenesis of Paclitaxel-induced painful neuropathy
H Zhang, SY Yoon, H Zhang, PM Dougherty - The Journal of Pain, 2012 - Elsevier
Paclitaxel often induces persistent painful neuropathy as its most common treatment-limiting
side effect. Little is known concerning the underlying mechanisms. Given the prominent role …
side effect. Little is known concerning the underlying mechanisms. Given the prominent role …
[HTML][HTML] Toll-like receptor 4 signaling contributes to Paclitaxel-induced peripheral neuropathy
Y Li, H Zhang, H Zhang, AK Kosturakis, AB Jawad… - The Journal of …, 2014 - Elsevier
This paper tests the contribution of the toll-like receptors, TLR4 in particular, in the initiation
and maintenance of paclitaxel-related chemotherapy-induced peripheral neuropathy. TLR4 …
and maintenance of paclitaxel-related chemotherapy-induced peripheral neuropathy. TLR4 …
Mechanical allodynia and enhanced responses to capsaicin are mediated by PI3K in a paclitaxel model of peripheral neuropathy
P Adamek, M Heles, J Palecek - Neuropharmacology, 2019 - Elsevier
Paclitaxel chemotherapy treatment often leads to neuropathic pain resistant to available
analgesic treatments. Recently spinal Toll-like receptor 4 (TLR4) and the transient receptor …
analgesic treatments. Recently spinal Toll-like receptor 4 (TLR4) and the transient receptor …
Paclitaxel‐induced neuropathic pain is age dependent and devolves on glial response
J Ruiz‐Medina, A Baulies, SA Bura… - European journal of …, 2013 - Wiley Online Library
Background Paclitaxel is an antimitotic antitumour drug highly effective against a broad
range of cancers considered refractory to conventional chemotherapy. One of the main …
range of cancers considered refractory to conventional chemotherapy. One of the main …
Involvement of the chemokine CCL3 and the purinoceptor p2× 7 in the spinal cord in paclitaxel-induced mechanical allodynia
R Ochi-Ishi, K Nagata, T Inoue… - Molecular …, 2014 - journals.sagepub.com
Background: Paclitaxel is an effective chemotherapeutic agent widely used for the treatment
of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The …
of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The …
Mechanisms underlying paclitaxel-induced neuropathic pain: Channels, inflammation and immune regulations
Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …
However, when paclitaxel is used to treat tumors, patients commonly experience severe …