Patients receiving paclitaxel for cancer treatment often develop an acute pain syndrome
(paclitaxel‐associated acute pain syndrome, P‐APS), which occurs immediately after …

Paclitaxel, a powerful anti-neoplastic drug, often causes pathological pain, which
significantly reduces the quality of life in patients. Paclitaxel-induced pain includes pain that …

Background Paclitaxel is a widely used and potent chemotherapeutic agent for the treatment
of cancer. However, patients receiving paclitaxel often develop an acute pain syndrome for …

Paclitaxel is a commonly used cancer chemotherapy drug that frequently causes painful
peripheral neuropathies. The mechanisms underlying this dose-limiting side effect are …

Paclitaxel often induces persistent painful neuropathy as its most common treatment-limiting
side effect. Little is known concerning the underlying mechanisms. Given the prominent role …

This paper tests the contribution of the toll-like receptors, TLR4 in particular, in the initiation
and maintenance of paclitaxel-related chemotherapy-induced peripheral neuropathy. TLR4 …

Paclitaxel chemotherapy treatment often leads to neuropathic pain resistant to available
analgesic treatments. Recently spinal Toll-like receptor 4 (TLR4) and the transient receptor …

Background Paclitaxel is an antimitotic antitumour drug highly effective against a broad
range of cancers considered refractory to conventional chemotherapy. One of the main …

Background: Paclitaxel is an effective chemotherapeutic agent widely used for the treatment
of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The …

Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …