Atomistic Characterization of Beta-2-Glycoprotein I Domain V Interaction with Anionic Membranes
Background: Interaction of beta-2-glycoprotein I (β2GPI) with anionic membranes is crucial
in antiphospholipid syndrome (APS), implicating the role of it′ s membrane binding …
in antiphospholipid syndrome (APS), implicating the role of it′ s membrane binding …
Identification of the phospholipid-binding site of human β2-glycoprotein I domain V by heteronuclear magnetic resonance
M Hoshino, Y Hagihara, I Nishii, T Yamazaki… - Journal of Molecular …, 2000 - Elsevier
To understand the mechanism of the interaction between human β2-glycoprotein I (β2-GPI)
and negatively charged phospholipids, we determined the three-dimensional solution …
and negatively charged phospholipids, we determined the three-dimensional solution …
X-ray and solution structures of human beta-2 glycoprotein I reveal a new mechanism of autoantibody recognition
E Ruben, W Planer, M Chinnaraj, Z Chen, X Zuo… - bioRxiv, 2020 - biorxiv.org
Venous and arterial thromboses in patients suffering from the autoimmune disorder
Antiphospholipid Syndrome (APS) are caused by the presence of antiphospholipid …
Antiphospholipid Syndrome (APS) are caused by the presence of antiphospholipid …
[HTML][HTML] Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding
I Buchholz, T McDonnell, P Nestler, S Tharad… - Scientific Reports, 2021 - nature.com
Abstract Beta-2-glycoprotein I (β2GPI) is a blood protein and the major antigen in the
autoimmune disorder antiphospholipid syndrome (APS). β2GPI exists mainly in closed or …
autoimmune disorder antiphospholipid syndrome (APS). β2GPI exists mainly in closed or …
[HTML][HTML] An allosteric redox switch in domain V of β2-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition
β 2-glycoprotein I (β 2 GPI) is an abundant multidomain plasma protein that plays various
roles in the clotting and complement cascades. It is also the main target of antiphospholipid …
roles in the clotting and complement cascades. It is also the main target of antiphospholipid …
[HTML][HTML] The J-elongated conformation of β2-glycoprotein I predominates in solution: Implications for our understanding of antiphospholipid syndrome
E Ruben, W Planer, M Chinnaraj, Z Chen, X Zuo… - Journal of Biological …, 2020 - ASBMB
β 2-Glycoprotein I (β 2 GPI) is an abundant plasma protein displaying phospholipid-binding
properties. Because it binds phospholipids, it is a target of antiphospholipid antibodies …
properties. Because it binds phospholipids, it is a target of antiphospholipid antibodies …
In silico identification of new inhibitors for βeta-2-glycoprotein I as a major antigen in antiphospholipid antibody syndrome
Beta 2 glycoprotein I (β2GPI) is a major antigen for autoantibodies present in
antiphospholipid antibody syndrome (APS). β2GPI is a single polypeptide with five repeated …
antiphospholipid antibody syndrome (APS). β2GPI is a single polypeptide with five repeated …
Membrane binding of β2-glycoprotein I can be described by a two-state reaction model: an atomic force microscopy and surface plasmon resonance study
R Gamsjaeger, A Johs, A Gries, HJ Gruber… - Biochemical …, 2005 - portlandpress.com
Complexes formed between β2GPI (β2-glycoprotein I), a human plasma protein, and
biological membranes are considered to be targets of macrophages and antiphospholipid …
biological membranes are considered to be targets of macrophages and antiphospholipid …
Cardiolipin interacts with beta‐2‐glycoprotein I and forms an open conformation–Mechanisms analyzed using hydrogen/deuterium exchange
Abstract Beta‐2‐glycoprotein I (β2GPI) is the major antigen for the antiphospholipid
antibodies in the antiphospholipid syndrome. The exposed epitope in domain I of β2GPI can …
antibodies in the antiphospholipid syndrome. The exposed epitope in domain I of β2GPI can …
Structural insights into recognition of β2‐glycoprotein I by the lipoprotein receptors
D Beglov, CJ Lee, A De Biasio… - Proteins: Structure …, 2009 - Wiley Online Library
The interactions of β2 glycoprotein I (B2GPI) with the receptors of the low‐density lipoprotein
receptor (LDLR) family are implicated in the clearance of negatively charged phospholipids …
receptor (LDLR) family are implicated in the clearance of negatively charged phospholipids …