Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Ultraviolet (UV) radiation–induced skin damage contributes strongly to the formation of
melanoma, a highly lethal form of skin cancer. Quercetin (Qu), the most widely consumed …

The bioactive components of dietary phytochemicals are in the spotlight of research
institutes, due to their significant antioxidant activities and health-promoting properties …

Treatment of melanoma has significantly advanced over the last decade, with the
development of targeted therapies against the MAPK pathway and immunotherapies to …

Dying tumor cells release biological signals that exhibit antigenicity, activate cytotoxic T
lymphocytes, and induce immunogenic cell death (ICD), playing a key role in immune …

Past studies have shown that melanoma cells have largely adapted to endoplasmic
reticulum (ER) stress. In this study, we report that melanoma cells under ER stress are more …

Background Pancreatic cancer (PC) remains the leading cause of cancer mortality, with
limited therapeutic targets, and alterations in endoplasmic reticulum (ER)-related …

Reduced expression and activity of the proapoptotic, double-stranded RNA-dependent
protein kinase, PKR (protein kinase R) is observed in breast, lung and various leukemias …

Oxidative stress is a critical factor for the development of cancer via inducing DNA mutations,
damage, and genome instability. Different signaling pathways associated with the …

Acute promyelocytic leukemia (APL) is characterized by a specific chromosomal translation,
resulting in a fusion gene that affects the differentiation, proliferation and apoptosis of APL …