Robert Dodge is the Laboratory Director for Immunochemistry and Cell Biology at Taylor
Technology, a Pharmanet company in Princeton, NJ, USA. Taylor Technology is a contract …

Administration of therapeutic proteins, including recombinant homologues of authentic
human proteins, can result in a loss of immune tolerance, leading to an immune response …

Assays for the detection and confirmation of anti-drug antibodies (ADA) are commonly used
tools for assessing the immunogenicity of drug candidates in both clinical and nonclinical …

Developing sensitive and specific bioanalytical assays for measuring the immunogenicity of
biological therapeutics has become an integral component of the drug-development …

Abstract Development of assays to reliably identify and characterize anti-drug antibodies
(ADAs) depends on positive control anti-idiotype (anti-id) reagents, which are used to …

Sensitive and specific methodology is required for the detection and characterization of anti-
drug antibodies (ADAs). High-quality ADA data enables the evaluation of potential impact of …

Anti‐drug antibodies induced by biologic therapeutics often impact drug pharmacokinetics,
pharmacodynamics response, clinical efficacy, and patient safety. It is critical to assess the …

Aim: Detection and characterization of antidrug antibodies (ADA) play a key role in
understanding the relation of ADA with safety and efficacy. Positive controls (PCs) are used …

Knowledge of the anti-drug antibody (ADA) status is necessary in early research studies.
Because specific assay materials are sparse and time is pressing, a generic assay format …

Background Increased emphasis on the development of biologics has placed a significant
focus on anti-drug antibody (ADA) detection. To address this need, several immunoassay …