Alzheimer's disease results from severe cytoskeletal alterations in only a few neuronal types
within the human central nervous system. These intraneuronal changes take the form of …

The unequivocal diagnosis of Alzheimer's disease (AD) rests on histopathological evidence
at brain autopsy or biopsy. The morphology of AD includes cerebral atrophy, deposition of …

Alzheimer's disease entails multiple neuronal systems and results from neuronal
cytoskeletal degeneration of only a few types of nerve cells. Essential for neuropathological …

Alzheimer's disease is an immutably progressing dementing disorder. Its major pathologic
hallmark is the gradual development of neurofibrillary changes in a few susceptible nerve …

Publisher Summary Alzheimer's disease and Parkinson's (Lewy body) disease, the most
widespread degenerative illnesses of the human brain, involve multiple neuronal systems …

The lesions of Alzheimer disease include accumulation of proteins, losses of neurons and
synapses, and alterations related to reactive processes. Extracellular Aβ accumulation …

Alois Alzheimer first pointed out that the disease which would later bear his name has a
distinct and recognizable neuropathological substrate. Since then, much has been added to …

The various structural components of the cortical degeneration of Alzheimer's disease were
defined and graded. The severity of the degenerative process was thus mapped in different …

Publisher Summary The chapter discusses the Alzheimer disease. It is described as a fatal
degenerative dementing disorder with initial mild memory impairment that progresses …

Alzheimer disease, a progressive neurodegenerative disorder of hitherto unknown etiology
leading progressively to severe incapacity and death, has become the pandemic of the 21 st …