Publisher Summary This chapter examines the different aspects of selective androgen
receptor modulators (SARMS). Testosterone (T) is an endogenous ligand for the androgen …

The androgen receptor mediates the androgenic and anabolic activity of the endogenous
steroids testosterone and 5alpha-dihydrotestosterone. Current knowledge of the androgen …

The androgen receptor (AR) is a nuclear hormone receptor that, upon binding to
testosterone, dihydrotestosterone (DHT) and other endogenous androgens, supports the …

Androgens are essential for male development and the maintenance of male secondary
characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis …

Selective androgen receptor modulators (SARMs) are small molecule drugs that function as
either androgen receptor (AR) agonists or antagonists. Variability in AR regulatory proteins …

Androgenic steroids are important for male development in utero and secondary sexual
characteristics at puberty. In addition, androgens play a role in non-reproductive tissues …

Androgens play an essential role in differentiation and growth of the male reproductive tract,
pubertal maturation and development of secondary male sex characteristics, initiation and …

Abstract The Androgen Receptor (AR), a member of the steroid hormone receptor family,
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …

Modulation of the androgen receptor has the potential to be an effective treatment for
hypogonadism, andropause, and associated conditions such as sarcopenia, osteoporosis …

Selective androgen receptor modulators (SARMs) are a novel class of androgen receptor
(AR) ligands that might change the future of androgen therapy dramatically. With improved …