Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma
Activating BRAF mutations that deregulate the mitogen-activated protein kinase (MAPK)
pathway commonly occur in cancer. BRAF V600E induces centrosome amplification and …
pathway commonly occur in cancer. BRAF V600E induces centrosome amplification and …
Oncogenic B-RafV600E abrogates the AKT/B-Raf/Mps1 interaction in melanoma cells
L Zhang, R Shi, C He, C Cheng, B Song, H Cui… - Cancer letters, 2013 - Elsevier
Activating B-Raf mutations that deregulate the mitogen-activated protein kinase (MAPK)
pathway commonly occur in cancer. Although B-Raf V600E induces increased Mps1 protein …
pathway commonly occur in cancer. Although B-Raf V600E induces increased Mps1 protein …
B-RafV600E signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells
Y Cui, TM Guadagno - Oncogene, 2008 - nature.com
Abstract The B-Raf V600E mutant, found in 65% of human melanomas, drives constitutive
activation of the extracellular signal-regulated kinase (ERK) pathway and is implicated in …
activation of the extracellular signal-regulated kinase (ERK) pathway and is implicated in …
Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis
R Darp, MA Vittoria, NJ Ganem, CJ Ceol - Nature Communications, 2022 - nature.com
Melanomas and other solid tumors commonly have increased ploidy, with near-tetraploid
karyotypes being most frequently observed. Such karyotypes have been shown to arise …
karyotypes being most frequently observed. Such karyotypes have been shown to arise …
Oncogenic B-RafV600E Induces Spindle Abnormalities, Supernumerary Centrosomes, and Aneuploidy in Human Melanocytic Cells
Y Cui, MK Borysova, JO Johnson, TM Guadagno - Cancer research, 2010 - AACR
Activating B-Raf mutations arise in 60% to 70% of human melanomas and are thought to
play a vital role in tumorigenesis, although how this occurs remains poorly understood. Wild …
play a vital role in tumorigenesis, although how this occurs remains poorly understood. Wild …
Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis
Background Proper execution of chromosome segregation relies on tight control of
attachment of chromosomes to spindle microtubules. This is monitored by the mitotic …
attachment of chromosomes to spindle microtubules. This is monitored by the mitotic …
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
The molecular pathogenesis of pediatric astrocytomas is still poorly understood. To further
understand the genetic abnormalities associated with these tumors, we performed a …
understand the genetic abnormalities associated with these tumors, we performed a …
Characterization of novel MPS1 inhibitors with preclinical anticancer activity
Abstract Monopolar spindle 1 (MPS1), a mitotic kinase that is overexpressed in several
human cancers, contributes to the alignment of chromosomes to the metaphase plate as …
human cancers, contributes to the alignment of chromosomes to the metaphase plate as …
The oncogenic functions of MASTL kinase
MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate
phosphorylation is correctly maintained. It achieves this through the phosphorylation of …
phosphorylation is correctly maintained. It achieves this through the phosphorylation of …
GNAQ and BRAF mutations show differential activation of the mTOR pathway in human transformed cells
Somatic mutations in GNAQ gene were described as being the main oncogenic activation in
uveal melanomas, whereas mutations in BRAF gene have been described as a key genetic …
uveal melanomas, whereas mutations in BRAF gene have been described as a key genetic …