Background Researchers and organizations often use evidence from randomized controlled
trials (RCTs) to determine the efficacy of a treatment or intervention under ideal conditions …

There are several methods in which one can assess the relationship between an
intervention and an outcome. Randomized controlled trials (RCTs) are considered as the …

Abstract Objective In both the United States and Europe there has been an increased
interest in using comparative effectiveness research of interventions to inform health policy …

Background There is controversy about the value of evidence about the effectiveness of
healthcare interventions from non-randomised study designs. Advocates for quasi …

Randomized controlled trials are considered the gold standard in the hierarchy of research
designs for evaluating the efficacy and safety of a treatment intervention. However, their …

Doctors, patients, and other decision makers need access to the best available clinical
evidence, which can come from systematic reviews, experimental trials, and observational …

Objectives To document reporting of study characteristics of randomized controlled trials
(RCTs) in the four leading general medical journals and to appraise the generalizability of …

OBJECTIVE: To describe a systematic approach for identifying, reporting, and synthesizing
information to allow consistent and transparent consideration of the applicability of the …

OBJECTIVES: To consider methods and related evidence for evaluating bias in non-
randomised intervention studies. DATA SOURCES: Systematic reviews and methodological …

This document updates the existing Agency for Healthcare Research and Quality (AHRQ)
Evidence-based Practice Center (EPC) Methods Guide for Effectiveness and Comparative …