A wide variety of models have been developed over the years to predict blood–brain barrier
(BBB) penetration, most of them have focussed on predicting total concentrations of drug …

Drug discovery programmes to target or avoid the brain need to take into account the
properties of the blood-brain barrier (BBB). The importance to CNS PK of the free drug …

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug
researchers about the blood-brain barrier (BBB) so they can affect important improvements …

Predictive, cost effective and fast evaluation of CNS penetration or unbound brain levels of
NCEs, or both, presents a considerable challenge in preclinical screening in the …

The development of drugs for central nervous system (CNS) disorders has encountered high
failure rates. In part, this has been due to the sole focus on blood-brain barrier permeability …

This Perspective provides important concepts about the blood–brain barrier (BBB) in drug
discovery and how they should be applied effectively in designing successful CNS drugs …

The properties of the blood–brain barrier (BBB) are important considerations when
designing drugs to target or avoid the brain. In vivo models provide some of the most reliable …

The brain is one of the most protected organs in the body. There are two key barriers that
control the access of endogenous substances and xenobiotics (drugs or toxins) to the CNS …

Assessing the rate of drug delivery to the central nervous system (CNS) in vitro has been
used for decades to predict whether CNS drug candidates are likely to attain their …

The development of CNS drugs is associated with high failure rates. It is postulated that too
much focus has been put on BBB permeability and too little on understanding BBB transport …